tert-butyl (2S,5R)-2-(4[({2-[(tert-butoxycarbonyl)amino]-5,6-dihydro-4H-cyclopenta[α][1,3]thiazol-4-yl}carbonyl)amino]benzyl)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (2S,5R)-2-(4[({2-[(tert-butoxycarbonyl)amino]-5,6-dihydro-4H-cyclopenta[α][1,3]thiazol-4-yl}carbonyl)amino]benzyl)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidine-1-carboxylate
CAS No.:1287760-56-8
Molecular Formula:C₃₅H₄₄N₄O₆S
Molecular Weight:648.824
Hs Code.:

tert-butyl (2S,5R)-2-(4[({2-[(tert-butoxycarbonyl)amino]-5,6-dihydro-4H-cyclopenta[α][1,3]thiazol-4-yl}carbonyl)amino]benzyl)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidine-1-carboxylate

Synonyms:tert-butyl (2S,5R)-2-(4[({2-[(tert-butoxycarbonyl)amino]-5,6-dihydro-4H-cyclopenta[α][1,3]thiazol-4-yl}carbonyl)amino]benzyl)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (2S,5R)-2-(4[({2-[(tert-butoxycarbonyl)amino]-5,6-dihydro-4H-cyclopenta[α][1,3]thiazol-4-yl}carbonyl)amino]benzyl)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (2S,5R)-2-(4[({2-[(tert-butoxycarbonyl)amino]-5,6-dihydro-4H-cyclopenta[α][1,3]thiazol-4-yl}carbonyl)amino]benzyl)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidine-1-carboxylate

There total 14 articles about tert-butyl (2S,5R)-2-(4[({2-[(tert-butoxycarbonyl)amino]-5,6-dihydro-4H-cyclopenta[α][1,3]thiazol-4-yl}carbonyl)amino]benzyl)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1190391-85-5
(2S,5R)-tert-butyl 2-(4-aminobenzyl)-5-((R)-hydroxy(phenyl)methyl)pyrrolidine-1-carboxylate

: 1190391-81-1
2-((tert-butoxycarbonyl)amino)-5,6-dihydro-4H-cyclopenta[d]thiazole-4-carboxylic acid

: 1287760-56-8
tert-butyl (2S,5R)-2-(4[({2-[(tert-butoxycarbonyl)amino]-5,6-dihydro-4H-cyclopenta[α][1,3]thiazol-4-yl}carbonyl)amino]benzyl)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidine-1-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1190391-85-5
(2S,5R)-tert-butyl 2-(4-aminobenzyl)-5-((R)-hydroxy(phenyl)methyl)pyrrolidine-1-carboxylate

: 1190391-81-1
2-((tert-butoxycarbonyl)amino)-5,6-dihydro-4H-cyclopenta[d]thiazole-4-carboxylic acid

: 1287760-56-8
tert-butyl (2S,5R)-2-(4[({2-[(tert-butoxycarbonyl)amino]-5,6-dihydro-4H-cyclopenta[α][1,3]thiazol-4-yl}carbonyl)amino]benzyl)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidine-1-carboxylate

: C₃₅H₄₄N₄O₆S

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1287760-56-8
tert-butyl (2S,5R)-2-(4[({2-[(tert-butoxycarbonyl)amino]-5,6-dihydro-4H-cyclopenta[α][1,3]thiazol-4-yl}carbonyl)amino]benzyl)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / water; ethyl acetate / 5 h / 20 - 45 °C

1.2: 7 h / 20 °C

1.3: 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 5 h / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide;