N-(4-methoxyphenyl)-2-<5-<<2-(dimethylamino)ethyl>carbamoyl>-2-nitrophenyl>-2-methylpropanamide

Base Information

Chemical Name:N-(4-methoxyphenyl)-2-<5-<<2-(dimethylamino)ethyl>carbamoyl>-2-nitrophenyl>-2-methylpropanamide
CAS No.:154078-44-1
Molecular Formula:C₂₂H₂₈N₄O₅
Molecular Weight:428.488
Hs Code.:

Synonyms:N-(4-methoxyphenyl)-2-<5-<<2-(dimethylamino)ethyl>carbamoyl>-2-nitrophenyl>-2-methylpropanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-methoxyphenyl)-2-<5-<<2-(dimethylamino)ethyl>carbamoyl>-2-nitrophenyl>-2-methylpropanamide

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Technology Process of N-(4-methoxyphenyl)-2-<5-<<2-(dimethylamino)ethyl>carbamoyl>-2-nitrophenyl>-2-methylpropanamide

There total 6 articles about N-(4-methoxyphenyl)-2-<5-<<2-(dimethylamino)ethyl>carbamoyl>-2-nitrophenyl>-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 108-00-9
N,N-dimethylethylenediamine

: 154078-91-8
N-(4-methoxyphenyl)-2-(5-carboxy-2-nitrophenyl)-2-methylpropanamide

: 154078-44-1
N-(4-methoxyphenyl)-2-<5-<<2-(dimethylamino)ethyl>carbamoyl>-2-nitrophenyl>-2-methylpropanamide

Guidance literature:: With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/jm00029a009

Reference yield:

: 154078-88-3
2-(5-carboxy-2-nitrophenyl)-2-methylpropanoic acid

: 154078-44-1
N-(4-methoxyphenyl)-2-<5-<<2-(dimethylamino)ethyl>carbamoyl>-2-nitrophenyl>-2-methylpropanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / conc. H₂SO₄ / 24 h / 20 °C

2: SOCl₂, DMF / 0.25 h / Heating

3: pyridine / 20 °C

4: 91 percent / aq. NaOH / methanol / Heating

5: 77 percent / 1,1'-carbonyldiimidazole / dimethylformamide / 0 - 20 °C

With pyridine; sodium hydroxide; thionyl chloride; sulfuric acid; N,N-dimethyl-formamide; 1,1'-carbonyldiimidazole; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00029a009

Reference yield:

: 154078-89-4
2-<5-(methoxycarbonyl)-2-nitrophenyl>-2-methylpropanoic acid

: 154078-44-1
N-(4-methoxyphenyl)-2-<5-<<2-(dimethylamino)ethyl>carbamoyl>-2-nitrophenyl>-2-methylpropanamide

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂, DMF / 0.25 h / Heating

2: pyridine / 20 °C

3: 91 percent / aq. NaOH / methanol / Heating

4: 77 percent / 1,1'-carbonyldiimidazole / dimethylformamide / 0 - 20 °C

With pyridine; sodium hydroxide; thionyl chloride; N,N-dimethyl-formamide; 1,1'-carbonyldiimidazole; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00029a009