C₄₁H₆₉NO₈Si

Base Information

• Chemical Name: C₄₁H₆₉NO₈Si
• CAS No.: 1403235-28-8
• Molecular Formula: C₄₁H₆₉NO₈Si
• Molecular Weight: 732.086
• Mol file: 1403235-28-8.mol

Synonyms:C₄₁H₆₉NO₈Si

Chemical Property of C₄₁H₆₉NO₈Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₁H₆₉NO₈Si

There total 15 articles about C₄₁H₆₉NO₈Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C35H55NO8 (1403235-27-7) → C41H69NO8Si (1403235-28-8)

Guidance literature:

With t-butyldimethylsiyl triflate; In dichloromethane; at -50 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol302309c

Reference yield:

C14H20O (1403235-36-8) → C41H69NO8Si (1403235-28-8)

Guidance literature:

Multi-step reaction with 12 steps

1.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / tert-butyl alcohol; water; tetrahydrofuran / 12 h / Inert atmosphere

1.2: 3 h / 0 - 20 °C / Inert atmosphere

2.1: di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

2.2: 1 h / 0 °C / Inert atmosphere

2.3: 6 h / -78 - 0 °C / Inert atmosphere

3.1: 2,6-dimethylpyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4.1: sodium tetrahydroborate / water; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

5.1: triethylamine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

6.1: copper dichloride; 1-Phenylprop-1-yne / tetrahydrofuran / 24 h / Inert atmosphere; Reflux

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

8.1: dmap / toluene / 3 h / 20 °C / Inert atmosphere

9.1: palladium 10% on activated carbon; hydrogen / methanol

10.1: 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate / dichloromethane / 2 h / 20 °C / Molecular sieve; Inert atmosphere

11.1: dicyclohexylboron chloride; N,N-dimethyl-ethanamine / diethyl ether; hexane / 1.5 h / 0 °C / Inert atmosphere

11.2: 26 h / -78 - -20 °C / Inert atmosphere

12.1: t-butyldimethylsiyl triflate / dichloromethane / 2 h / -50 °C / Inert atmosphere

With 2,6-dimethylpyridine; 1-Phenylprop-1-yne; dmap; sodium tetrahydroborate; osmium(VIII) oxide; tetrapropylammonium perruthennate; N,N-dimethyl-ethanamine; di-n-butylboryl trifluoromethanesulfonate; palladium 10% on activated carbon; t-butyldimethylsiyl triflate; dicyclohexylboron chloride; tetrabutyl ammonium fluoride; hydrogen; 4-methylmorpholine N-oxide; triethylamine; copper dichloride; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; toluene; tert-butyl alcohol; 2.1: |Evans Aldol Reaction / 2.2: |Evans Aldol Reaction / 2.3: |Evans Aldol Reaction;

DOI:10.1021/ol302309c

Reference yield:

(3S)-5-(benzyloxy)-3-methylpentanal (82538-49-6) → C41H69NO8Si (1403235-28-8)

Guidance literature:

Multi-step reaction with 11 steps

1.1: di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

1.2: 1 h / 0 °C / Inert atmosphere

1.3: 6 h / -78 - 0 °C / Inert atmosphere

2.1: 2,6-dimethylpyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3.1: sodium tetrahydroborate / water; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4.1: triethylamine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

5.1: copper dichloride; 1-Phenylprop-1-yne / tetrahydrofuran / 24 h / Inert atmosphere; Reflux

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

7.1: dmap / toluene / 3 h / 20 °C / Inert atmosphere

8.1: palladium 10% on activated carbon; hydrogen / methanol

9.1: 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate / dichloromethane / 2 h / 20 °C / Molecular sieve; Inert atmosphere

10.1: dicyclohexylboron chloride; N,N-dimethyl-ethanamine / diethyl ether; hexane / 1.5 h / 0 °C / Inert atmosphere

10.2: 26 h / -78 - -20 °C / Inert atmosphere

11.1: t-butyldimethylsiyl triflate / dichloromethane / 2 h / -50 °C / Inert atmosphere

With 2,6-dimethylpyridine; 1-Phenylprop-1-yne; dmap; sodium tetrahydroborate; tetrapropylammonium perruthennate; N,N-dimethyl-ethanamine; di-n-butylboryl trifluoromethanesulfonate; palladium 10% on activated carbon; t-butyldimethylsiyl triflate; dicyclohexylboron chloride; tetrabutyl ammonium fluoride; hydrogen; 4-methylmorpholine N-oxide; triethylamine; copper dichloride; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; toluene; 1.1: |Evans Aldol Reaction / 1.2: |Evans Aldol Reaction / 1.3: |Evans Aldol Reaction;

DOI:10.1021/ol302309c

upstream raw materials:

C₁₄H₂₀O

(3S)-5-(benzyloxy)-3-methylpentanal

C₂₆H₃₃NO₅

C₃₂H₄₇NO₅Si