1-(5-O-(4,4'-dimethoxytrityl)-3-O-(triethylsilyl)-3-C-(1-hydroxy-1-phentlmethyl)-2-deoxy-β-D-threo-pentofuranosyl)thymine

Base Information

Chemical Name:1-(5-O-(4,4'-dimethoxytrityl)-3-O-(triethylsilyl)-3-C-(1-hydroxy-1-phentlmethyl)-2-deoxy-β-D-threo-pentofuranosyl)thymine
CAS No.:220928-54-1
Molecular Formula:C₄₄H₅₂N₂O₈Si
Molecular Weight:764.991
Hs Code.:

Synonyms:1-(5-O-(4,4'-dimethoxytrityl)-3-O-(triethylsilyl)-3-C-(1-hydroxy-1-phentlmethyl)-2-deoxy-β-D-threo-pentofuranosyl)thymine

Suppliers and Price of 1-(5-O-(4,4'-dimethoxytrityl)-3-O-(triethylsilyl)-3-C-(1-hydroxy-1-phentlmethyl)-2-deoxy-β-D-threo-pentofuranosyl)thymine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(5-O-(4,4'-dimethoxytrityl)-3-O-(triethylsilyl)-3-C-(1-hydroxy-1-phentlmethyl)-2-deoxy-β-D-threo-pentofuranosyl)thymine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(5-O-(4,4'-dimethoxytrityl)-3-O-(triethylsilyl)-3-C-(1-hydroxy-1-phentlmethyl)-2-deoxy-β-D-threo-pentofuranosyl)thymine

There total 4 articles about 1-(5-O-(4,4'-dimethoxytrityl)-3-O-(triethylsilyl)-3-C-(1-hydroxy-1-phentlmethyl)-2-deoxy-β-D-threo-pentofuranosyl)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 100-58-3
phenylmagnesium bromide

: 220928-46-1
1-(5-O-(4,4'-dimethoxytrityl)-3-O-(triethylsilyl)-3-C-formyl-2-deoxy-β-D-threo-pentofuranosyl)thymine

: 220928-54-1
1-(5-O-(4,4'-dimethoxytrityl)-3-O-(triethylsilyl)-3-C-(1-hydroxy-1-phentlmethyl)-2-deoxy-β-D-threo-pentofuranosyl)thymine

Guidance literature:: With cerium(III) chloride; In tetrahydrofuran; at -10 ℃; for 3h;
DOI:10.1021/jo982022y

Reference yield:

: 154468-74-3
5'-O-(4,4'-dimethoxytrityl)-3'-C-(hydroxymethyl)thymidine

: 220928-54-1
1-(5-O-(4,4'-dimethoxytrityl)-3-O-(triethylsilyl)-3-C-(1-hydroxy-1-phentlmethyl)-2-deoxy-β-D-threo-pentofuranosyl)thymine

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / imidazole / dimethylformamide / 24 h / 25 °C

2: 77 percent / HF, pyridine / tetrahydrofuran / 7 h / 0 °C

3: 98 percent / TPAP, NMO, 4 Angstroems MS / CH₂Cl₂ / 1 h

4: 31 percent / CeCl₃ / tetrahydrofuran / 3 h / -10 °C

With pyridine; 1H-imidazole; N-methyl-2-indolinone; cerium(III) chloride; tetrapropylammonium perruthennate; 4 Angstroems MS; hydrogen fluoride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo982022y

Reference yield:

: 220928-45-0
1-(5-O-(4,4'-dimethoxytrityl)-3-O-(triethylsilyl)-3-C-(hydroxymethyl)-2-deoxy-β-D-threo-pentofuranosyl)thymine

: 220928-54-1
1-(5-O-(4,4'-dimethoxytrityl)-3-O-(triethylsilyl)-3-C-(1-hydroxy-1-phentlmethyl)-2-deoxy-β-D-threo-pentofuranosyl)thymine

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / TPAP, NMO, 4 Angstroems MS / CH₂Cl₂ / 1 h

2: 31 percent / CeCl₃ / tetrahydrofuran / 3 h / -10 °C

With N-methyl-2-indolinone; cerium(III) chloride; tetrapropylammonium perruthennate; 4 Angstroems MS; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo982022y