methyl 4'-hydroxy-4-[2-(trifluoromethanesulfonyloxy)benzoyl]biphenyl-2-carboxylate

Base Information

• Chemical Name: methyl 4'-hydroxy-4-[2-(trifluoromethanesulfonyloxy)benzoyl]biphenyl-2-carboxylate
• CAS No.: 1189760-28-8
• Molecular Formula: C₂₂H₁₅F₃O₇S
• Molecular Weight: 480.418
• Mol file: 1189760-28-8.mol

Synonyms:methyl 4'-hydroxy-4-[2-(trifluoromethanesulfonyloxy)benzoyl]biphenyl-2-carboxylate

Chemical Property of methyl 4'-hydroxy-4-[2-(trifluoromethanesulfonyloxy)benzoyl]biphenyl-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4'-hydroxy-4-[2-(trifluoromethanesulfonyloxy)benzoyl]biphenyl-2-carboxylate

There total 2 articles about methyl 4'-hydroxy-4-[2-(trifluoromethanesulfonyloxy)benzoyl]biphenyl-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

methyl 2-(trifluoromethanesulfonyloxy)-5-[2-(trifluoromethanesulfonyloxy)benzoyl]benzoate (1189760-11-9) + (p-hydroxyphenyl)boronic acid (71597-85-8) → methyl 4'-hydroxy-4-[2-(trifluoromethanesulfonyloxy)benzoyl]biphenyl-2-carboxylate (1189760-28-8)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 110 ℃; for 4h;

DOI:10.1055/s-0029-1217544

Reference yield:

3-Formylchromone (17422-74-1) → methyl 4'-hydroxy-4-[2-(trifluoromethanesulfonyloxy)benzoyl]biphenyl-2-carboxylate (1189760-28-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 0 °C / Inert atmosphere

1.2: 12 h / 0 - 20 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: pyridine / dichloromethane / 0.17 h / -78 °C / Inert atmosphere

2.2: 4 h / -78 - 0 °C / Inert atmosphere

3.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 4 h / 110 °C / Inert atmosphere

With pyridine; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trimethylsilyl trifluoromethanesulfonate; In 1,4-dioxane; dichloromethane; 3.1: Suzuki coupling;

DOI:10.1002/ejoc.201100762

Reference yield: 74.0%

methyl 4'-hydroxy-4-[2-(trifluoromethanesulfonyloxy)benzoyl]biphenyl-2-carboxylate (1189760-28-8) + 4-Vinylphenylboronic acid (2156-04-9,593231-72-2) → methyl 4'-hydroxy-4-((4'-vinylbiphenyl-2-yl)carbonyl)biphenyl-2-carboxylate (1189760-31-3)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 110 ℃; for 4h; Inert atmosphere;

DOI:10.1002/ejoc.201100762

upstream raw materials:

methyl 2-(trifluoromethanesulfonyloxy)-5-[2-(trifluoromethanesulfonyloxy)benzoyl]benzoate

(p-hydroxyphenyl)boronic acid

3-Formylchromone

Downstream raw materials:

methyl 4'-hydroxy-4-((4'-vinylbiphenyl-2-yl)carbonyl)biphenyl-2-carboxylate