C₂₀H₂₂F₆N₂O₃

Base Information

Chemical Name:C₂₀H₂₂F₆N₂O₃
CAS No.:1416560-76-3
Molecular Formula:C₂₀H₂₂F₆N₂O₃
Molecular Weight:452.397
Hs Code.:

C<sub>20</sub>H<sub>22</sub>F<sub>6</sub>N<sub>2</sub>O<sub>3</sub>

Synonyms:C₂₀H₂₂F₆N₂O₃

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Chemical Property of C₂₀H₂₂F₆N₂O₃

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Technology Process of C₂₀H₂₂F₆N₂O₃

There total 6 articles about C₂₀H₂₂F₆N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1416560-75-2
C₁₉H₂₂F₆N₂O₄

: 1416560-76-3
C₂₀H₂₂F₆N₂O₃

Guidance literature:: With dimethyl 1-(1-diazo-2-oxopropyl)phosphonate; potassium carbonate; In methanol; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.10.124

Reference yield:

: 210491-38-6
4-bromo-2,6-bis(trifluoromethyl)benzoic acid

: 1416560-76-3
C₂₀H₂₂F₆N₂O₃

Guidance literature:: Multi-step reaction with 6 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 0.08 h / 0 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

3: triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 60 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C / Inert atmosphere

5: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide; dichloromethane / 0.25 h / 20 °C / Inert atmosphere

6: dimethyl 1-(1-diazo-2-oxopropyl)phosphonate; potassium carbonate / methanol / 12 h / 20 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diethylamino-sulfur trifluoride; palladium 10% on activated carbon; hydrogen; sulfur trioxide pyridine complex; dimethyl 1-(1-diazo-2-oxopropyl)phosphonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.10.124

Reference yield:

: 1416560-72-9
C₁₆H₁₇BrF₆N₂O₃

: 1416560-76-3
C₂₀H₂₂F₆N₂O₃

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 60 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C / Inert atmosphere

3: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide; dichloromethane / 0.25 h / 20 °C / Inert atmosphere

4: dimethyl 1-(1-diazo-2-oxopropyl)phosphonate; potassium carbonate / methanol / 12 h / 20 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sulfur trioxide pyridine complex; dimethyl 1-(1-diazo-2-oxopropyl)phosphonate; potassium carbonate; triethylamine; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.10.124