4-Bromo-2,6-bis(trifluoromethyl)benzoyl fluoride

Base Information

Chemical Name:4-Bromo-2,6-bis(trifluoromethyl)benzoyl fluoride
CAS No.:210491-39-7
Molecular Formula:C₉H₂BrF₇O
Molecular Weight:339.007
Hs Code.:
DSSTox Substance ID:DTXSID401239307

Synonyms:4-bromo-2,6-bis(trifluoromethyl)benzoyl fluoride;210491-39-7;DTXSID401239307

Suppliers and Price of 4-Bromo-2,6-bis(trifluoromethyl)benzoyl fluoride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-Bromo-2,6-bis(trifluoromethyl)benzoyl fluoride

Chemical Property:

XLogP3:4.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:1
Exact Mass:337.91772
Heavy Atom Count:18
Complexity:300

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=C(C=C(C(=C1C(F)(F)F)C(=O)F)C(F)(F)F)Br

Technology Process of 4-Bromo-2,6-bis(trifluoromethyl)benzoyl fluoride

There total 3 articles about 4-Bromo-2,6-bis(trifluoromethyl)benzoyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 210491-38-6
4-bromo-2,6-bis(trifluoromethyl)benzoic acid

: 210491-39-7
4-Bromo-2,6-bis-trifluoromethyl-benzoyl fluoride

Guidance literature:: With sulfur tetrafluoride; hydrogen fluoride; In water; 1.) 20 deg C, 20 h, 2.) 120 deg C, 3 h;
DOI:10.1016/S0040-4020(98)00362-7

Reference yield:

: 402-31-3
1,3-bis(trifluoromethyl)benzene

: 210491-39-7
4-Bromo-2,6-bis-trifluoromethyl-benzoyl fluoride

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) t-BuOK, n-BuLi / 1.) THF, hexane, -95 deg C, 7 h, 2.) overnight

2: 92 percent / DBDMH, conc. H₂SO₄ / 1.) 0-5 deg C, 2 h, 2.) overnight, room temperature

3: 75 percent / SF₄, HF / H₂O / 1.) 20 deg C, 20 h, 2.) 120 deg C, 3 h

With n-butyllithium; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid; sulfur tetrafluoride; hydrogen fluoride; potassium tert-butylate; In water;
DOI:10.1016/S0040-4020(98)00362-7

Reference yield:

: 24821-22-5
2,6-bis(trifluoromethyl)benzoic acid

: 210491-39-7
4-Bromo-2,6-bis-trifluoromethyl-benzoyl fluoride

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / DBDMH, conc. H₂SO₄ / 1.) 0-5 deg C, 2 h, 2.) overnight, room temperature

2: 75 percent / SF₄, HF / H₂O / 1.) 20 deg C, 20 h, 2.) 120 deg C, 3 h

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid; sulfur tetrafluoride; hydrogen fluoride; In water;
DOI:10.1016/S0040-4020(98)00362-7