Technology Process of N-benzyl-N-(4-methylpenta-2,3-dien-1-yl)-2-acetylpent-4-enamide
There total 8 articles about N-benzyl-N-(4-methylpenta-2,3-dien-1-yl)-2-acetylpent-4-enamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-benzyl-N-(4-methylpenta-2,3-dien-1-yl)-2-acetylacetamide;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 0 - 20 ℃;
for 0.333333h;
Inert atmosphere;
allyl bromide;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
for 16h;
Inert atmosphere;
DOI:10.1002/chem.201103902
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / 0 - 20 °C / Inert atmosphere
1.2: 4 h / 55 °C / Inert atmosphere
2.1: potassium carbonate / methanol; water / 16 h / 50 °C / Inert atmosphere
3.1: 5,5-dimethyl-1,3-cyclohexadiene / 2 h / 125 °C
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 - 20 °C / Inert atmosphere
4.2: 16 h / 20 °C / Inert atmosphere
With
sodium hydride; potassium carbonate; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/chem.201103902
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: dmap / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / 0 - 20 °C / Inert atmosphere
2.2: 4 h / 55 °C / Inert atmosphere
3.1: potassium carbonate / methanol; water / 16 h / 50 °C / Inert atmosphere
4.1: 5,5-dimethyl-1,3-cyclohexadiene / 2 h / 125 °C
5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 - 20 °C / Inert atmosphere
5.2: 16 h / 20 °C / Inert atmosphere
With
dmap; sodium hydride; potassium carbonate; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/chem.201103902
