1-benzyl-3-acetyl-3-allyl-4-(2-methylprop-1-en-1-yl)pyrrolidin-2-one

Base Information

Chemical Name:1-benzyl-3-acetyl-3-allyl-4-(2-methylprop-1-en-1-yl)pyrrolidin-2-one
CAS No.:1379935-91-7
Molecular Formula:C₂₀H₂₅NO₂
Molecular Weight:311.424
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-benzyl-3-acetyl-3-allyl-4-(2-methylprop-1-en-1-yl)pyrrolidin-2-one

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Technology Process of 1-benzyl-3-acetyl-3-allyl-4-(2-methylprop-1-en-1-yl)pyrrolidin-2-one

There total 10 articles about 1-benzyl-3-acetyl-3-allyl-4-(2-methylprop-1-en-1-yl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1379935-80-4
N-benzyl-N-(4-methylpenta-2,3-dien-1-yl)-2-acetylpent-4-enamide

: 1379935-91-7
1-benzyl-3-acetyl-3-allyl-4-(2-methylprop-1-en-1-yl)pyrrolidin-2-one

Guidance literature:: With tetra(n-butyl)ammonium hydroxide; gold bromide; In methanol; cyclohexane; at 80 ℃; for 3h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/chem.201103902

Reference yield:

: 100-46-9
benzylamine

: 1379935-91-7
1-benzyl-3-acetyl-3-allyl-4-(2-methylprop-1-en-1-yl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / 0 - 20 °C / Inert atmosphere

2.2: 4 h / 55 °C / Inert atmosphere

3.1: potassium carbonate / methanol; water / 16 h / 50 °C / Inert atmosphere

4.1: 5,5-dimethyl-1,3-cyclohexadiene / 2 h / 125 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 - 20 °C / Inert atmosphere

5.2: 16 h / 20 °C / Inert atmosphere

6.1: tetra(n-butyl)ammonium hydroxide; gold bromide / methanol; cyclohexane / 3 h / 80 °C / Inert atmosphere

With dmap; tetra(n-butyl)ammonium hydroxide; gold bromide; sodium hydride; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; cyclohexane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/chem.201103902

Reference yield:

: 1379935-48-4
4-methylpenta-2,3-dienyl 2-phenylacetate

: 1379935-91-7
1-benzyl-3-acetyl-3-allyl-4-(2-methylprop-1-en-1-yl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / 0 - 20 °C / Inert atmosphere

1.2: 4 h / 55 °C / Inert atmosphere

2.1: potassium carbonate / methanol; water / 16 h / 50 °C / Inert atmosphere

3.1: 5,5-dimethyl-1,3-cyclohexadiene / 2 h / 125 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 - 20 °C / Inert atmosphere

4.2: 16 h / 20 °C / Inert atmosphere

5.1: tetra(n-butyl)ammonium hydroxide; gold bromide / methanol; cyclohexane / 3 h / 80 °C / Inert atmosphere

With tetra(n-butyl)ammonium hydroxide; gold bromide; sodium hydride; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; cyclohexane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/chem.201103902