1,1-dimethylethyl 2-<3-bromo-5-<<-4-cyclopropyl-2-ethyl-5-<(ethylamino)carbonyl>-1H-imidazol-1-yl>methyl>-2-benzofuranyl>benzoate

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Chemical Name:1,1-dimethylethyl 2-<3-bromo-5-<<-4-cyclopropyl-2-ethyl-5-<(ethylamino)carbonyl>-1H-imidazol-1-yl>methyl>-2-benzofuranyl>benzoate
CAS No.:146623-87-2
Molecular Formula:C₃₁H₃₄BrN₃O₄
Molecular Weight:592.533
Hs Code.:

Synonyms:1,1-dimethylethyl 2-<3-bromo-5-<<-4-cyclopropyl-2-ethyl-5-<(ethylamino)carbonyl>-1H-imidazol-1-yl>methyl>-2-benzofuranyl>benzoate

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Chemical Property of 1,1-dimethylethyl 2-<3-bromo-5-<<-4-cyclopropyl-2-ethyl-5-<(ethylamino)carbonyl>-1H-imidazol-1-yl>methyl>-2-benzofuranyl>benzoate

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Technology Process of 1,1-dimethylethyl 2-<3-bromo-5-<<-4-cyclopropyl-2-ethyl-5-<(ethylamino)carbonyl>-1H-imidazol-1-yl>methyl>-2-benzofuranyl>benzoate

There total 12 articles about 1,1-dimethylethyl 2-<3-bromo-5-<<-4-cyclopropyl-2-ethyl-5-<(ethylamino)carbonyl>-1H-imidazol-1-yl>methyl>-2-benzofuranyl>benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1025993-01-4
3-Cyclopropyl-2-nitro-3-oxo-propionic acid ethyl ester

: 146623-87-2
1,1-dimethylethyl 2-<3-bromo-5-<<-4-cyclopropyl-2-ethyl-5-<(ethylamino)carbonyl>-1H-imidazol-1-yl>methyl>-2-benzofuranyl>benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / H₂, AcCl / 5percent Pd/C / ethanol / 5 h / 760 Torr / Ambient temperature

2: 24 percent / Et₃N / ethanol

3: 30 percent / K₂CO₃ / dimethylformamide / 40 h / Ambient temperature

4: 59 percent / aq. NaOH / methanol / 3 h / Heating

5: 1.) CDI / 1.) CH₂Cl₂, RT, 1 h, 2.) CH₂Cl₂, a) RT, 20 h, b) reflux, 4 h

With sodium hydroxide; hydrogen; potassium carbonate; triethylamine; acetyl chloride; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00045a016

Reference yield:

: 24922-02-9
Ethyl 3-cyclopropyl-3-oxopropionate

: 146623-87-2
1,1-dimethylethyl 2-<3-bromo-5-<<-4-cyclopropyl-2-ethyl-5-<(ethylamino)carbonyl>-1H-imidazol-1-yl>methyl>-2-benzofuranyl>benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 72 percent / aq. NaNO₂ / acetic acid / 4 h / Ambient temperature

2: 60 percent / H₂, AcCl / 5percent Pd/C / ethanol / 5 h / 760 Torr / Ambient temperature

3: 24 percent / Et₃N / ethanol

4: 30 percent / K₂CO₃ / dimethylformamide / 40 h / Ambient temperature

5: 59 percent / aq. NaOH / methanol / 3 h / Heating

6: 1.) CDI / 1.) CH₂Cl₂, RT, 1 h, 2.) CH₂Cl₂, a) RT, 20 h, b) reflux, 4 h

With sodium hydroxide; hydrogen; potassium carbonate; triethylamine; acetyl chloride; 1,1'-carbonyldiimidazole; sodium nitrite; palladium on activated charcoal; In methanol; ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00045a016

Reference yield:

: 18441-43-5
5-methylbenzofuran

: 146623-87-2
1,1-dimethylethyl 2-<3-bromo-5-<<-4-cyclopropyl-2-ethyl-5-<(ethylamino)carbonyl>-1H-imidazol-1-yl>methyl>-2-benzofuranyl>benzoate

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) n-BuLi, TMEDA, 2.) triisopropyl borate, 3.) tetrakis(triphenylphosphine)palladium, Na₂CO₃

2: 100 percent / Br₂ / CCl₄ / 0.67 h / 0 - 5 °C

3: 92 percent / aq. NaOH / methanol / 3 h / Heating

4: 94 percent / toluene / 1 h / 80 °C

5: 70 percent / NBS / CCl₄ / 3 h / Heating

6: 30 percent / K₂CO₃ / dimethylformamide / 40 h / Ambient temperature

7: 59 percent / aq. NaOH / methanol / 3 h / Heating

8: 1.) CDI / 1.) CH₂Cl₂, RT, 1 h, 2.) CH₂Cl₂, a) RT, 20 h, b) reflux, 4 h

With sodium hydroxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; Triisopropyl borate; N,N,N,N,-tetramethylethylenediamine; bromine; sodium carbonate; potassium carbonate; 1,1'-carbonyldiimidazole; In methanol; tetrachloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00045a016