8-(1-(4-fluorophenylamino)ethyl)-N,N-dimethyl-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide

Base Information

Chemical Name:8-(1-(4-fluorophenylamino)ethyl)-N,N-dimethyl-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide
CAS No.:1296271-25-4
Molecular Formula:C₂₅H₂₈FN₃O₄
Molecular Weight:453.513
Hs Code.:

Synonyms:8-(1-(4-fluorophenylamino)ethyl)-N,N-dimethyl-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide

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Chemical Property of 8-(1-(4-fluorophenylamino)ethyl)-N,N-dimethyl-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide

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Technology Process of 8-(1-(4-fluorophenylamino)ethyl)-N,N-dimethyl-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide

There total 17 articles about 8-(1-(4-fluorophenylamino)ethyl)-N,N-dimethyl-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1296271-74-3
8-(1-bromoethyl)-N,N-dimethyl-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide hydrobromide

: 371-40-4
4-fluoroaniline

: 1296271-25-4
8-(1-(4-fluorophenylamino)ethyl)-N,N-dimethyl-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide

Guidance literature:: In ISOPROPYLAMIDE; at 20 ℃; for 4h;

Reference yield: 59.0%

: 8-(1-bromoethyl)-N,N-dimethyl-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide hydrobromide

: 371-40-4
4-fluoroaniline

: 1296271-25-4
8-(1-(4-fluorophenylamino)ethyl)-N,N-dimethyl-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide

Guidance literature:: In ISOPROPYLAMIDE; at 20 ℃; for 4h;

Reference yield:

: 99-76-3,156291-94-0
methyl 4-hydroxylbenzoate

: 1296271-25-4
8-(1-(4-fluorophenylamino)ethyl)-N,N-dimethyl-2-((R)-2-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide

Guidance literature:: Multi-step reaction with 13 steps

1.1: bromine / dichloromethane / 36 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / palladium diacetate; (diphenylphosphin)ferrocene / diethyl ether; ethanol / 70 °C / Inert atmosphere

2.2: 2 h

3.1: bromine; pyridine / dichloromethane / 2 h / 0 - 20 °C

3.2: 5 °C

4.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.25 h / -50 - 0 °C / Inert atmosphere

4.2: 24 h / -20 - 20 °C

4.3: -50 °C

5.1: potassium carbonate / acetone / 2 h / 60 °C / Inert atmosphere

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 10 - 20 °C / Inert atmosphere

8.1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 4 h / 90 °C / Inert atmosphere

8.2: 1 h / 20 °C

9.1: sodium tetrahydroborate / dichloromethane; methanol / 0.25 h / -10 °C

10.1: sodium hydroxide; water / methanol / 1 h / 20 °C

10.2: pH 2 - 3

11.1: O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 10 - 20 °C / Inert atmosphere

11.2: 10 - 20 °C

12.1: phosphorus tribromide / 1,2-dichloro-ethane / 1 h / 10 - 50 °C / Inert atmosphere

13.1: ISOPROPYLAMIDE / 4 h / 20 °C

With pyridine; sodium tetrahydroborate; water; bromine; sodium hexamethyldisilazane; phosphorus tribromide; potassium carbonate; O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; (diphenylphosphin)ferrocene; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; ISOPROPYLAMIDE; 1,2-dichloro-ethane; acetone;