Technology Process of methyl 7-(2-bromo-4-fluorobenzenesulfonylamino)-1,2,3,3a,4,5-hexahydro-pyrrolo[1,2-a]quinoline-6-carboxylate
There total 11 articles about methyl 7-(2-bromo-4-fluorobenzenesulfonylamino)-1,2,3,3a,4,5-hexahydro-pyrrolo[1,2-a]quinoline-6-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridine;
In
dichloromethane;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 - -30 °C / Inert atmosphere
1.2: -30 - -10 °C
2.1: lithium chloride / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 95 °C / Inert atmosphere
3.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h
4.1: N-Bromosuccinimide / acetonitrile / 1 h / 20 °C
5.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
6.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 1 h / 100 °C / Inert atmosphere
7.1: sulfuric acid / methanol / 100 h / 20 °C / Reflux
8.1: pyridine / dichloromethane / 2 h / 20 °C
With
pyridine; N-Bromosuccinimide; n-butyllithium; sulfuric acid; hydrogen; caesium carbonate; trifluoroacetic acid; lithium chloride;
bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: sodium hydrogencarbonate / ethyl acetate; water
2: pyridine / dichloromethane / 1 h / Cooling with ice
3: lithium chloride / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 95 °C / Inert atmosphere
4: hydrogen / palladium 10% on activated carbon / ethanol / 4 h
5: N-Bromosuccinimide / acetonitrile / 1 h / 20 °C
6: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
7: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 1 h / 100 °C / Inert atmosphere
8: sulfuric acid / methanol / 100 h / 20 °C / Reflux
9: pyridine / dichloromethane / 2 h / 20 °C
With
pyridine; N-Bromosuccinimide; sulfuric acid; hydrogen; sodium hydrogencarbonate; caesium carbonate; trifluoroacetic acid; lithium chloride;
bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
