N-{4-[3-(2-chlorophenyl)-4-(4H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]-5-methylpyridin-2-yl}acetamide

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Chemical Name:N-{4-[3-(2-chlorophenyl)-4-(4H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]-5-methylpyridin-2-yl}acetamide
CAS No.:1445888-28-7
Molecular Formula:C₁₉H₁₆ClN₇O
Molecular Weight:393.835
Hs Code.:

Synonyms:N-{4-[3-(2-chlorophenyl)-4-(4H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]-5-methylpyridin-2-yl}acetamide

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Chemical Property of N-{4-[3-(2-chlorophenyl)-4-(4H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]-5-methylpyridin-2-yl}acetamide

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Technology Process of N-{4-[3-(2-chlorophenyl)-4-(4H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]-5-methylpyridin-2-yl}acetamide

There total 12 articles about N-{4-[3-(2-chlorophenyl)-4-(4H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]-5-methylpyridin-2-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445890-08-3
N-{5-bromo-4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]pyridin-2-yl}acetamide

: potassium trifluoro(methyl)boranuide

: 1445888-28-7
N-{4-[3-(2-chlorophenyl)-4-(1H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]-5-methylpyridin-2-yl}acetamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,2-dimethoxyethane; water; at 150 ℃; for 2h; Sealed tube; Microwave irradiation;

Reference yield:

: 1445889-92-8
methyl 3-(2-chlorophenyl)-1H-pyrazole-4-carboxylate

: 1445888-28-7
N-{4-[3-(2-chlorophenyl)-4-(1H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]-5-methylpyridin-2-yl}acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper diacetate; pyridine / N,N-dimethyl-formamide / 6 h / 150 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 20 °C

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; ammonia; triethylamine / dichloromethane; 1,4-dioxane / 20 °C

4.1: N,N-dimethyl-formamide; toluene / 50 °C

4.2: 2 h / 20 °C

With pyridine; ammonia; water; copper diacetate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 205985-98-4
methyl 2-chlorobenzoylacetate

: 1445888-28-7
N-{4-[3-(2-chlorophenyl)-4-(1H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]-5-methylpyridin-2-yl}acetamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: 3 h / 20 - 60 °C

2.1: hydrazine hydrate / acetic acid / 20 °C

3.1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate / 1,4-dioxane / 3 h / Reflux; Inert atmosphere

4.1: sodium hydroxide; water / tetrahydrofuran / 80 °C

5.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 0.25 h / 20 °C

5.2: 20 °C

6.1: toluene / 2 h / 50 °C

6.2: 3 h / 20 °C

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 - 20 °C / Inert atmosphere

7.2: 1.5 h / 0 °C

8.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 1 h / 130 °C / Sealed tube; Microwave irradiation

9.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 85 °C

10.1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,2-dimethoxyethane / 2 h / 150 °C / Sealed tube; Microwave irradiation

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; copper(l) iodide; water; sodium hydride; sodium carbonate; potassium carbonate; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrazine hydrate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene; mineral oil;