Technology Process of phenyl 2,3,4-tri-O-benzyl-6-deoxy-6-fluoro-1-thio-β-D-glucopyranoside
There total 4 articles about phenyl 2,3,4-tri-O-benzyl-6-deoxy-6-fluoro-1-thio-β-D-glucopyranoside which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
phenyl 6-deoxy-6-fluoro-1-thio-β-D-glucopyranoside;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 0 - 20 ℃;
benzyl bromide;
With
tetra-(n-butyl)ammonium iodide;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
DOI:10.1055/s-0031-1289598
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium methylate / methanol / 8 h / 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C
2.2: 20 °C
With
sodium methylate; sodium hydride;
In
methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1055/s-0031-1289598
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: boron trifluoride diethyl etherate / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere
2.1: sodium methylate / methanol / 8 h / 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C
3.2: 20 °C
With
boron trifluoride diethyl etherate; sodium methylate; sodium hydride;
In
methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1055/s-0031-1289598
