ethyl 7-(4-(trifluoromethyl)phenyl)-4-hydroxy-2-naphthoate

Base Information

• Chemical Name: ethyl 7-(4-(trifluoromethyl)phenyl)-4-hydroxy-2-naphthoate
• CAS No.: 1160269-99-7
• Molecular Formula: C₂₀H₁₅F₃O₃
• Molecular Weight: 360.333
• Mol file: 1160269-99-7.mol

Synonyms:ethyl 7-(4-(trifluoromethyl)phenyl)-4-hydroxy-2-naphthoate

Chemical Property of ethyl 7-(4-(trifluoromethyl)phenyl)-4-hydroxy-2-naphthoate

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of ethyl 7-(4-(trifluoromethyl)phenyl)-4-hydroxy-2-naphthoate

There total 1 articles about ethyl 7-(4-(trifluoromethyl)phenyl)-4-hydroxy-2-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-trifluoromethylphenylboronic acid (128796-39-4) + 7-Bromo-4-hydroxynaphthalene-2-carboxylic acid ethyl ester (178876-99-8) → ethyl 7-(4-(trifluoromethyl)phenyl)-4-hydroxy-2-naphthoate (1160269-99-7)

Guidance literature:

4-trifluoromethylphenylboronic acid; 7-Bromo-4-hydroxynaphthalene-2-carboxylic acid ethyl ester; With sodium carbonate; In N,N-dimethyl-formamide; Inert atmosphere;

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 85 ℃; for 2.5h; Inert atmosphere;

DOI:10.1124/mol.113.085654

Reference yield: 69.0%

ethyl 7-(4-(trifluoromethyl)phenyl)-4-hydroxy-2-naphthoate (1160269-99-7) → 4-hydroxy-7-(4-(trifluoromethyl)phenyl)-2-naphthoic acid

Guidance literature:

With potassium hydroxide; In methanol; water; at 70 ℃; for 1h;

DOI:10.1021/acs.jmedchem.8b00168

Reference yield:

trifluoromethylsulfonic anhydride (358-23-6) + ethyl 7-(4-(trifluoromethyl)phenyl)-4-hydroxy-2-naphthoate (1160269-99-7) → ethyl 7-(4-(trifluoromethyl)phenyl)-4-(((trifluoromethyl)sulfonyl)oxy)-2-naphthoate (1160270-01-8)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 3h;

upstream raw materials:

4-trifluoromethylphenylboronic acid

7-Bromo-4-hydroxynaphthalene-2-carboxylic acid ethyl ester

Downstream raw materials:

ethyl 7-(4-(trifluoromethyl)phenyl)-4-(((trifluoromethyl)sulfonyl)oxy)-2-naphthoate

C₂₃H₁₅F₃O₄S₂

C₂₅H₁₇F₃O₄S

4-[4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthoic acid