ethyl 7-(4-(trifluoromethyl)phenyl)-4-(((trifluoromethyl)sulfonyl)oxy)-2-naphthoate

Base Information

• Chemical Name: ethyl 7-(4-(trifluoromethyl)phenyl)-4-(((trifluoromethyl)sulfonyl)oxy)-2-naphthoate
• CAS No.: 1160270-01-8
• Molecular Formula: C₂₁H₁₄F₆O₅S
• Molecular Weight: 492.396
• Mol file: 1160270-01-8.mol

Synonyms:ethyl 7-(4-(trifluoromethyl)phenyl)-4-(((trifluoromethyl)sulfonyl)oxy)-2-naphthoate

Chemical Property of ethyl 7-(4-(trifluoromethyl)phenyl)-4-(((trifluoromethyl)sulfonyl)oxy)-2-naphthoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 7-(4-(trifluoromethyl)phenyl)-4-(((trifluoromethyl)sulfonyl)oxy)-2-naphthoate

There total 3 articles about ethyl 7-(4-(trifluoromethyl)phenyl)-4-(((trifluoromethyl)sulfonyl)oxy)-2-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trifluoromethylsulfonic anhydride (358-23-6) + ethyl 7-(4-(trifluoromethyl)phenyl)-4-hydroxy-2-naphthoate (1160269-99-7) → ethyl 7-(4-(trifluoromethyl)phenyl)-4-(((trifluoromethyl)sulfonyl)oxy)-2-naphthoate (1160270-01-8)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

4-trifluoromethylphenylboronic acid (128796-39-4) → ethyl 7-(4-(trifluoromethyl)phenyl)-4-(((trifluoromethyl)sulfonyl)oxy)-2-naphthoate (1160270-01-8)

Guidance literature:

Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / N,N-dimethyl-formamide / 85 °C

2: pyridine / dichloromethane

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.03.081

Reference yield:

7-Bromo-4-hydroxynaphthalene-2-carboxylic acid ethyl ester (178876-99-8) → ethyl 7-(4-(trifluoromethyl)phenyl)-4-(((trifluoromethyl)sulfonyl)oxy)-2-naphthoate (1160270-01-8)

Guidance literature:

Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / N,N-dimethyl-formamide / 85 °C

2: pyridine / dichloromethane

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.03.081

upstream raw materials:

trifluoromethylsulfonic anhydride

ethyl 7-(4-(trifluoromethyl)phenyl)-4-hydroxy-2-naphthoate

4-trifluoromethylphenylboronic acid

7-Bromo-4-hydroxynaphthalene-2-carboxylic acid ethyl ester

Downstream raw materials:

ethyl 7-(4-(trifluoromethyl)phenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-naphthoate

ethyl 4-{4-[(1R)-2,2-difluoro-1-hydroxyethyl]phenyl}-7-[4-(trifluoromethyl)phenyl]-2-naphthoate

ethyl 4-[4-(methylsulfinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthoate

ethyl 4-[5-(2,2-difluoro-1-hydroxyethyl)-3-thienyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthoate