{4-(methylethylidene)-5-oxo-2-[(phenylmethoxy)methyl]-2-2,3-dihydrofuryl}methyl 4-[2-(4-ethynylphenyl)ethynyl]benzoate

Base Information

• Chemical Name: {4-(methylethylidene)-5-oxo-2-[(phenylmethoxy)methyl]-2-2,3-dihydrofuryl}methyl 4-[2-(4-ethynylphenyl)ethynyl]benzoate
• CAS No.: 932711-38-1
• Molecular Formula: C₃₃H₂₈O₅
• Molecular Weight: 504.582
• Mol file: 932711-38-1.mol

Synonyms:{4-(methylethylidene)-5-oxo-2-[(phenylmethoxy)methyl]-2-2,3-dihydrofuryl}methyl 4-[2-(4-ethynylphenyl)ethynyl]benzoate

Chemical Property of {4-(methylethylidene)-5-oxo-2-[(phenylmethoxy)methyl]-2-2,3-dihydrofuryl}methyl 4-[2-(4-ethynylphenyl)ethynyl]benzoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of {4-(methylethylidene)-5-oxo-2-[(phenylmethoxy)methyl]-2-2,3-dihydrofuryl}methyl 4-[2-(4-ethynylphenyl)ethynyl]benzoate

There total 1 articles about {4-(methylethylidene)-5-oxo-2-[(phenylmethoxy)methyl]-2-2,3-dihydrofuryl}methyl 4-[2-(4-ethynylphenyl)ethynyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[2-(4-ethynylphenyl)ethynyl]benzoic acid (866825-55-0) + 5-(hydroxymethyl)-3-(methylethylidene)-5-[(phenylmethoxy)methyl]-4,5-dihydrofuran-2-one (932711-33-6) → {4-(methylethylidene)-5-oxo-2-[(phenylmethoxy)methyl]-2-2,3-dihydrofuryl}methyl 4-[2-(4-ethynylphenyl)ethynyl]benzoate (932711-38-1)

Guidance literature:

With dmap; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In dichloromethane; for 1h;

DOI:10.1021/jm061289j

Reference yield: 50.0%

{4-(methylethylidene)-5-oxo-2-[(phenylmethoxy)methyl]-2-2,3-dihydrofuryl}methyl 4-[2-(4-ethynylphenyl)ethynyl]benzoate (932711-38-1) + para-iodoanisole (696-62-8) → {4-(methylethylidene)-5-oxo-2-[(phenylmethoxy)methyl]-2-2,3-dihydrofuryl}methyl 4-(2-{4-[2-(4-ethynylphenyl)ethynyl]phenyl}ethynyl)benzoate + C66H54O10

Guidance literature:

With caesium carbonate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; for 5h;

DOI:10.1021/jm061289j

Reference yield:

{4-(methylethylidene)-5-oxo-2-[(phenylmethoxy)methyl]-2-2,3-dihydrofuryl}methyl 4-[2-(4-ethynylphenyl)ethynyl]benzoate (932711-38-1) → 4-[4-(4-methoxy-phenylethynyl)-phenylethynyl]-benzoic acid 2-hydroxymethyl-4-isopropylidene-5-oxo-tetrahydro-furan-2-ylmethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / Cs₂CO₃ / PdCl₂(PPh₃)2; CuI / tetrahydrofuran / 5 h

2: 60 percent / BCl₃ / CH₂Cl₂ / 1.5 h / -78 °C

With boron trichloride; caesium carbonate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; dichloromethane; 1: Sonogashira coupling;

DOI:10.1021/jm061289j

upstream raw materials:

4-[2-(4-ethynylphenyl)ethynyl]benzoic acid

5-(hydroxymethyl)-3-(methylethylidene)-5-[(phenylmethoxy)methyl]-4,5-dihydrofuran-2-one