4-((4-Ethynylphenyl)ethynyl)benzoic acid

Base Information

• Chemical Name: 4-((4-Ethynylphenyl)ethynyl)benzoic acid
• CAS No.: 866825-55-0
• Molecular Formula: C17H10O2
• Molecular Weight: 246.265
• Mol file: 866825-55-0.mol

Synonyms:4-((4-Ethynylphenyl)ethynyl)benzoic acid;4-[2-(4-ethynylphenyl)ethynyl]Benzoic acid

Chemical Property of 4-((4-Ethynylphenyl)ethynyl)benzoic acid

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

99% ，98% ^*data from raw suppliers

4-((4-Ethynylphenyl)ethynyl)benzoic acid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-((4-Ethynylphenyl)ethynyl)benzoic acid

There total 17 articles about 4-((4-Ethynylphenyl)ethynyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

heptyl 4-((4-((trimethylsilyl)ethynyl)phenyl)ethynyl)benzoate → 4-[2-(4-ethynylphenyl)ethynyl]benzoic acid (866825-55-0)

Guidance literature:

With lithium hydroxide; In methanol; water; at 60 ℃;

DOI:10.1021/jacs.1c10327

Reference yield: 65.0%

4-iodobenzoic acid (619-58-9) + 1,4-diethynylbenzene (935-14-8) → 4-[2-(4-ethynylphenyl)ethynyl]benzoic acid (866825-55-0)

Guidance literature:

DOI:10.1039/b516782e

Reference yield:

ethyl 4-[2-(4-bromophenyl)ethynyl]benzoate (866825-52-7) → 4-[2-(4-ethynylphenyl)ethynyl]benzoic acid (866825-55-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / PPh₃; PdCl₂(PPh₃)2; CuI / triethylamine; pyridine / 96 h

2: KOH / butan-1-ol / 2 h / Heating

With bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide; copper(l) iodide; triphenylphosphine; pyridine; triethylamine; In butan-1-ol; 1: Sonogashira coupling;

DOI:10.1021/ja053120l

upstream raw materials:

ethyl 4-{2-[4-(3-hydroxy-3-methyl-1-butynyl)phenyl]ethynyl}benzoate

3,3-dimethyl-3-silabutyl 4-{2-[4-(3,3-dimethyl-3-silabut-1-ynyl)phenyl]ethynyl}benzoate

4-iodobenzoic acid

1,4-diethynylbenzene

Downstream raw materials:

5-(4-[4-[4-(4-carboxy-phenylethynyl)-phenylethynyl]phenylethynyl]phenylethynyl)-10,20-biphenylporphyrinato zinc(II)

4-{4-[4-(2-{2-[2-(bis-tert-butoxycarbonylmethyl-carbamoyloxy)-ethoxy]-ethoxy}-ethoxy)-phenylethynyl]-phenylethynyl}-benzoic acid 2-hydroxymethyl-4-isopropylidene-5-oxo-tetrahydro-furan-2-ylmethyl ester

4-(4-ethynyl-phenylethynyl)-benzoic acid 2-hydroxymethyl-4-isopropylidene-5-oxo-tetrahydro-furan-2-ylmethyl ester

{2-[(4-methoxyphenoxy)methyl]-4-(methylethylidene)-5-oxo-2-2,3-dihydrofuryl}methyl 4-[2-(4-ethynylphenyl)ethynyl]benzoate

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