1-[(4-methylphenyl)sulfonyl]-5-(trifluoromethyl)-1H-indole

Base Information

• Chemical Name: 1-[(4-methylphenyl)sulfonyl]-5-(trifluoromethyl)-1H-indole
• CAS No.: 1420069-56-2
• Molecular Formula: C₁₆H₁₂F₃NO₂S
• Molecular Weight: 339.338
• Mol file: 1420069-56-2.mol

Synonyms:1-[(4-methylphenyl)sulfonyl]-5-(trifluoromethyl)-1H-indole

Chemical Property of 1-[(4-methylphenyl)sulfonyl]-5-(trifluoromethyl)-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-[(4-methylphenyl)sulfonyl]-5-(trifluoromethyl)-1H-indole

There total 9 articles about 1-[(4-methylphenyl)sulfonyl]-5-(trifluoromethyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-(2-ethynyl-4-(trifluoromethyl)phenyl)-4-methylbenzenesulfonamide (1186610-43-4) → 1-[(4-methylphenyl)sulfonyl]-5-(trifluoromethyl)-1H-indole (1420069-56-2)

Guidance literature:

With potassium carbonate; In water; at 130 ℃; for 10h; Sealed tube; Inert atmosphere;

DOI:10.1016/j.cclet.2016.07.022

Reference yield: 72.0%

p-toluenesulfonyl chloride (98-59-9) + 5-trifluoromethyl-1H-indole (100846-24-0) → 1-[(4-methylphenyl)sulfonyl]-5-(trifluoromethyl)-1H-indole (1420069-56-2)

Guidance literature:

5-trifluoromethyl-1H-indole; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 1h; Cooling with ice;

p-toluenesulfonyl chloride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

Reference yield: 72.0%

C16H14F3NO2S → 1-[(4-methylphenyl)sulfonyl]-5-(trifluoromethyl)-1H-indole (1420069-56-2)

Guidance literature:

With potassium thioacyanate; tertamethylammonium iodide; In water; acetonitrile; at 80 ℃; Electrochemical reaction;

DOI:10.1021/acs.orglett.0c01821

upstream raw materials:

p-toluenesulfonyl chloride

5-trifluoromethyl-1H-indole

5-nitroindole

N-(2-ethynyl-4-(trifluoromethyl)phenyl)-4-methylbenzenesulfonamide