N-ethyl-N-({2-[1-[(4-methylphenyl)sulfonyl]-5-(trifluoromethyl)-1H-indol-3-yl]pyridin-3-yl}methyl)cyclopropanecarboxamide

Base Information

Chemical Name:N-ethyl-N-({2-[1-[(4-methylphenyl)sulfonyl]-5-(trifluoromethyl)-1H-indol-3-yl]pyridin-3-yl}methyl)cyclopropanecarboxamide
CAS No.:1420069-58-4
Molecular Formula:C₂₈H₂₆F₃N₃O₃S
Molecular Weight:541.594
Hs Code.:

Synonyms:N-ethyl-N-({2-[1-[(4-methylphenyl)sulfonyl]-5-(trifluoromethyl)-1H-indol-3-yl]pyridin-3-yl}methyl)cyclopropanecarboxamide

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Chemical Property of N-ethyl-N-({2-[1-[(4-methylphenyl)sulfonyl]-5-(trifluoromethyl)-1H-indol-3-yl]pyridin-3-yl}methyl)cyclopropanecarboxamide

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Technology Process of N-ethyl-N-({2-[1-[(4-methylphenyl)sulfonyl]-5-(trifluoromethyl)-1H-indol-3-yl]pyridin-3-yl}methyl)cyclopropanecarboxamide

There total 4 articles about N-ethyl-N-({2-[1-[(4-methylphenyl)sulfonyl]-5-(trifluoromethyl)-1H-indol-3-yl]pyridin-3-yl}methyl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1420068-56-9
N-[(2-chloropyridin-3-yl)methyl]-N-ethylcyclopropanecarboxamide

: 1420069-57-3
[1-[(4-methylphenyl)sulfonyl]-5-(trifluoromethyl)-1H-indol-3-yl]boronic acid

: 1420069-58-4
N-ethyl-N-({2-[1-[(4-methylphenyl)sulfonyl]-5-(trifluoromethyl)-1H-indol-3-yl]pyridin-3-yl}methyl)cyclopropanecarboxamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In toluene; at 90 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1420069-56-2
1-[(4-methylphenyl)sulfonyl]-5-(trifluoromethyl)-1H-indole

: 1420069-58-4
N-ethyl-N-({2-[1-[(4-methylphenyl)sulfonyl]-5-(trifluoromethyl)-1H-indol-3-yl]pyridin-3-yl}methyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid; mercury(II) diacetate / 20 °C

1.2: 2 h

1.3: 2 h

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene / 2 h / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; mercury(II) diacetate; sodium carbonate; acetic acid; In toluene;

Reference yield:

: 100846-24-0
5-trifluoromethyl-1H-indole

: 1420069-58-4
N-ethyl-N-({2-[1-[(4-methylphenyl)sulfonyl]-5-(trifluoromethyl)-1H-indol-3-yl]pyridin-3-yl}methyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1 h / 0 °C / Cooling with ice

1.2: 0.5 h / 20 °C

2.1: acetic acid; mercury(II) diacetate / 20 °C

2.2: 2 h

2.3: 2 h

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene / 2 h / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; mercury(II) diacetate; sodium hydride; sodium carbonate; acetic acid; In N,N-dimethyl-formamide; toluene; mineral oil;