tert-butyl (1-(4-((6-chloro-3-nitropyridin-2-yl)amino)phenyl)cyclobutyl)carbamate

Base Information

Chemical Name:tert-butyl (1-(4-((6-chloro-3-nitropyridin-2-yl)amino)phenyl)cyclobutyl)carbamate
CAS No.:1313883-38-3
Molecular Formula:C₂₀H₂₃ClN₄O₄
Molecular Weight:418.88
Hs Code.:

Synonyms:tert-butyl (1-(4-((6-chloro-3-nitropyridin-2-yl)amino)phenyl)cyclobutyl)carbamate

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Chemical Property of tert-butyl (1-(4-((6-chloro-3-nitropyridin-2-yl)amino)phenyl)cyclobutyl)carbamate

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Technology Process of tert-butyl (1-(4-((6-chloro-3-nitropyridin-2-yl)amino)phenyl)cyclobutyl)carbamate

There total 4 articles about tert-butyl (1-(4-((6-chloro-3-nitropyridin-2-yl)amino)phenyl)cyclobutyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 16013-85-7,136901-10-5
2,6-dicholoro-3-nitropyridine

: 1259224-00-4
[1-(4-amino-phenyl)-cyclobutyl]-carbamic acid tert-butyl ester

: 1313883-38-3
tert-butyl (1-(4-((6-chloro-3-nitropyridin-2-yl)amino)phenyl)cyclobutyl)carbamate

Guidance literature:: With triethylamine; In N,N-dimethyl acetamide; at 0 - 20 ℃;

Reference yield:

: 16013-85-7,136901-10-5
2,6-dicholoro-3-nitropyridine

: C₁₆H₂₃NO₂

: 1313883-38-3
tert-butyl (1-(4-((6-chloro-3-nitropyridin-2-yl)amino)phenyl)cyclobutyl)carbamate

Guidance literature:: In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1259223-99-8
4-(1-((tert-butoxycarbonyl)amino)cyclobutyl)benzoic acid

: 1313883-38-3
tert-butyl (1-(4-((6-chloro-3-nitropyridin-2-yl)amino)phenyl)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diphenylphosphoranyl azide; triethylamine / toluene / 2 h / 100 °C

1.2: 2 h / 100 °C

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 20 °C

3.1: triethylamine / N,N-dimethyl acetamide / 0 - 20 °C

With palladium 10% on activated carbon; diphenylphosphoranyl azide; hydrogen; triethylamine; In methanol; N,N-dimethyl acetamide; ethyl acetate; toluene;