2-[(2-([4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL]AMINO)-2-OXOETHYL)SULFANYL]ACETIC ACID

Base Information

• Chemical Name: 2-[(2-([4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL]AMINO)-2-OXOETHYL)SULFANYL]ACETIC ACID
• CAS No.: 477867-80-4
• Molecular Formula: C₁₃H₁₁ClN₂O₃S₂
• Molecular Weight: 342.827
• Mol file: 477867-80-4.mol

Synonyms:2-((2-((4-(4-chlorophenyl)thiazol-2-yl)amino)-2-oxoethyl)thio)acetic acid

Chemical Property of 2-[(2-([4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL]AMINO)-2-OXOETHYL)SULFANYL]ACETIC ACID

Chemical Property:

Purity/Quality:

2-[(2-{[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]amino}-2-oxoethyl)sulfanyl]acetic acid ^*data from reagent suppliers

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Technology Process of 2-[(2-([4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL]AMINO)-2-OXOETHYL)SULFANYL]ACETIC ACID

There total 3 articles about 2-[(2-([4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL]AMINO)-2-OXOETHYL)SULFANYL]ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-chloro-N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]acetamide (6125-31-1) + mercaptoacetic acid (68-11-1) → 2-((2-((4-(4-chlorophenyl)thiazol-2-yl)amino)-2-oxoethyl)thio)acetic acid (477867-80-4)

Guidance literature:

2-chloro-N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]acetamide; mercaptoacetic acid; With sodium hydroxide; In methanol; Reflux;

With hydrogenchloride; In methanol; water; Cooling with ice;

DOI:10.1002/ardp.201300115

Reference yield:

para-chloroacetophenone (99-91-2) → 2-((2-((4-(4-chlorophenyl)thiazol-2-yl)amino)-2-oxoethyl)thio)acetic acid (477867-80-4)

Guidance literature:

Multi-step reaction with 4 steps

1: copper(ll) bromide / ethanol; chloroform; ethyl acetate / 0.5 h / 65 °C

2: ethanol / 2 h / Reflux

3: triethylamine / N,N-dimethyl-formamide / 10 °C

4: triethylamine / tetrahydrofuran / 35 °C

With triethylamine; copper(ll) bromide; In tetrahydrofuran; ethanol; chloroform; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2012.03.006

Reference yield:

4-(4-chlorophenyl)-2-thiazolamine (2103-99-3) → 2-((2-((4-(4-chlorophenyl)thiazol-2-yl)amino)-2-oxoethyl)thio)acetic acid (477867-80-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: benzene

2.1: sodium hydroxide / methanol / Reflux

2.2: Cooling with ice

With sodium hydroxide; In methanol; benzene;

DOI:10.1002/ardp.201300115

upstream raw materials:

2-chloro-N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]acetamide

mercaptoacetic acid

para-chloroacetophenone

4-(4-chlorophenyl)-2-thiazolamine

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