(2R,3S,5R)-3-(t-butyldimethylsilyloxy)-2-(4,4'-dimethoxytrityloxymethyl)-5-(1-methylpyrimidin-2,4-dion-5-ylethynyl)tetrahydrofuran

Base Information

Chemical Name:(2R,3S,5R)-3-(t-butyldimethylsilyloxy)-2-(4,4'-dimethoxytrityloxymethyl)-5-(1-methylpyrimidin-2,4-dion-5-ylethynyl)tetrahydrofuran
CAS No.:1402090-84-9
Molecular Formula:C₃₉H₄₆N₂O₇Si
Molecular Weight:682.889
Hs Code.:

Synonyms:(2R,3S,5R)-3-(t-butyldimethylsilyloxy)-2-(4,4'-dimethoxytrityloxymethyl)-5-(1-methylpyrimidin-2,4-dion-5-ylethynyl)tetrahydrofuran

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Chemical Property of (2R,3S,5R)-3-(t-butyldimethylsilyloxy)-2-(4,4'-dimethoxytrityloxymethyl)-5-(1-methylpyrimidin-2,4-dion-5-ylethynyl)tetrahydrofuran

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Technology Process of (2R,3S,5R)-3-(t-butyldimethylsilyloxy)-2-(4,4'-dimethoxytrityloxymethyl)-5-(1-methylpyrimidin-2,4-dion-5-ylethynyl)tetrahydrofuran

There total 1 articles about (2R,3S,5R)-3-(t-butyldimethylsilyloxy)-2-(4,4'-dimethoxytrityloxymethyl)-5-(1-methylpyrimidin-2,4-dion-5-ylethynyl)tetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1039665-17-2
(2R,3S,5R)-2-(4,4'-dimethoxytrityloxymethyl)-3-hydroxy-5-(1-methylpyrimidin-2,4-dion-5-ylethynyl)tetrahydrofuran

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1402090-84-9
(2R,3S,5R)-3-(t-butyldimethylsilyloxy)-2-(4,4'-dimethoxytrityloxymethyl)-5-(1-methylpyrimidin-2,4-dion-5-ylethynyl)tetrahydrofuran

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1016/j.tet.2012.08.057

Reference yield:

: 1402090-84-9
(2R,3S,5R)-3-(t-butyldimethylsilyloxy)-2-(4,4'-dimethoxytrityloxymethyl)-5-(1-methylpyrimidin-2,4-dion-5-ylethynyl)tetrahydrofuran

: 1402090-86-1
C₅₄H₆₂N₅O₁₄PSi

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichloroacetic acid / dichloromethane / 0.25 h / 20 °C

2.1: 1H-tetrazole / acetonitrile / 0.25 h / 20 °C

2.2: 0.08 h / 20 °C

With 1H-tetrazole; trichloroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2012.08.057