Technology Process of 3-methyl-2-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclohex-2-enone
There total 6 articles about 3-methyl-2-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclohex-2-enone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-methylcyclohexen-2-one;
With
sodium hydride;
In
dimethyl sulfoxide; mineral oil;
at 16 - 20 ℃;
for 0.5h;
2-methyl-2-(2-iodoethyl)-1,3-dioxolane;
In
dimethyl sulfoxide; mineral oil;
for 17h;
DOI:10.3390/molecules25040831
- Guidance literature:
-
Multi-step reaction with 3 steps
1: LDA
2: 48 percent / aq. nickel acetate / ethanol / 70 °C
3: 57 percent / 10percent NaOH / aq. ethanol / 30 °C / further conditions: reflux, 25 min; further reagent: lithium hexamethyldisilazide; further solvent: tetrahydrofuran; further temperature: -78 deg C
With
sodium hydroxide; nickel diacetate; lithium diisopropyl amide;
In
ethanol;
DOI:10.1246/cl.1988.1109
- Guidance literature:
-
Multi-step reaction with 4 steps
1: LDA
2: LDA
3: 48 percent / aq. nickel acetate / ethanol / 70 °C
4: 57 percent / 10percent NaOH / aq. ethanol / 30 °C / further conditions: reflux, 25 min; further reagent: lithium hexamethyldisilazide; further solvent: tetrahydrofuran; further temperature: -78 deg C
With
sodium hydroxide; nickel diacetate; lithium diisopropyl amide;
In
ethanol;
DOI:10.1246/cl.1988.1109
