3,3-dimethyl-2-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclohexanone

Base Information

• Chemical Name: 3,3-dimethyl-2-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclohexanone
• CAS No.: 77239-50-0
• Molecular Formula: C₁₄H₂₄O₃
• Molecular Weight: 240.343
• Mol file: 77239-50-0.mol

Synonyms:3,3-dimethyl-2-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclohexanone

Chemical Property of 3,3-dimethyl-2-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclohexanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,3-dimethyl-2-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclohexanone

There total 6 articles about 3,3-dimethyl-2-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C14H24O4 → 3,3-dimethyl-2-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclohexanone (77239-50-0)

Guidance literature:

C₁₄H₂₄O₄; With dmap; methanesulfonyl chloride; In dichloromethane; Inert atmosphere; Reflux;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 23 ℃; Inert atmosphere;

With hydrogen; palladium(II) hydroxide; sodium hydrogencarbonate; In ethyl acetate;

DOI:10.1021/acs.joc.0c02273

Reference yield: 92.0%

3-methyl-2-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclohex-2-enone (38275-12-6) + methyllithium (917-54-4) → 3,3-dimethyl-2-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclohexanone (77239-50-0)

Guidance literature:

methyllithium; With copper(l) iodide; In diethyl ether; at -78 - -10 ℃;

3-methyl-2-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclohex-2-enone; In diethyl ether; at -40 ℃; for 0.5h;

DOI:10.3390/molecules25040831

Reference yield: 40.0%

2-methyl-2-vinyl-1,3-dioxolane (26924-35-6) + 3,3-dimethyl-1-<(trimethylsilyl)oxy>cyclohex-1-ene (61175-92-6) → 3,3-Dimethyl-2-(3-oxo-butyl)-cyclohexanone (77239-51-1) + 3,3-dimethyl-2-(2-(2-methyl-1,3-dioxolan-2-yl)ethyl)cyclohexanone (77239-50-0)

Guidance literature:

With titanium(IV) isopropylate; titanium tetrachloride; In dichloromethane; at -78 ℃; for 1h;

DOI:10.1246/cl.1980.1257

upstream raw materials:

2-methyl-2-vinyl-1,3-dioxolane

3,3-dimethyl-1-<(trimethylsilyl)oxy>cyclohex-1-ene

3-methylcyclohexen-2-one

2-methyl-2-(2-iodoethyl)-1,3-dioxolane

Downstream raw materials:

dihydro-γ-ionone ethylene acetal

β-ambrinol

(+/-)-α-ambrinol