tert-butoxycarbonyl-L-tyrosine pentachlorophenyl ester

Base Information

• Chemical Name: tert-butoxycarbonyl-L-tyrosine pentachlorophenyl ester
• CAS No.: 40472-66-0
• Molecular Formula: C₂₀H₁₈Cl₅NO₅
• Molecular Weight: 529.632
• Mol file: 40472-66-0.mol

Synonyms:tert-butoxycarbonyl-L-tyrosine pentachlorophenyl ester

Chemical Property of tert-butoxycarbonyl-L-tyrosine pentachlorophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of tert-butoxycarbonyl-L-tyrosine pentachlorophenyl ester

There total 1 articles about tert-butoxycarbonyl-L-tyrosine pentachlorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Pentachlorophenol (87-86-5,67471-28-7) + Boc-Tyr-OH (3978-80-1) → tert-butoxycarbonyl-L-tyrosine pentachlorophenyl ester (40472-66-0)

Guidance literature:

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1002/hlca.19730560420

Reference yield: 65.0%

tert-butoxycarbonyl-L-tyrosine pentachlorophenyl ester (40472-66-0) + H-Phe-Phe-Gly-Leu-Met-NH2 (51165-05-0,78081-73-9) → Boc-Tyr-Phe-Phe-Gly-Leu-Met-NH2 (73149-12-9)

Guidance literature:

DOI:10.1016/0223-5234(88)90006-2

Reference yield: 62.0%

tert-butoxycarbonyl-L-tyrosine pentachlorophenyl ester (40472-66-0) → N-(tert-butyloxycarbonyl)-L-tyrosinol (83345-46-4,282100-80-5)

Guidance literature:

With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 20 ℃;

DOI:10.1039/a902069a

upstream raw materials:

Pentachlorophenol

Boc-Tyr-OH

Downstream raw materials:

Boc-Tyr-Phe-Phe-Gly-Leu-Met-NH₂

N-(tert-butyloxycarbonyl)-L-tyrosinol

tert-butoxycarbonyl-L-tyrosyl-glycyl-glycine

Boc-Tyr-D-Met-Gly-OH

Refernces