S,S-diphenyl N²-(4,4',4''-trimethoxytrityl)-2',3'-O-methoxymethyleneguanosine 5'-phosphorodithioate

Base Information

• Chemical Name: S,S-diphenyl N²-(4,4',4''-trimethoxytrityl)-2',3'-O-methoxymethyleneguanosine 5'-phosphorodithioate
• CAS No.: 118573-14-1
• Molecular Formula: C₄₆H₄₄N₅O₁₀PS₂
• Molecular Weight: 921.989
• Mol file: 118573-14-1.mol

Synonyms:S,S-diphenyl N²-(4,4',4''-trimethoxytrityl)-2',3'-O-methoxymethyleneguanosine 5'-phosphorodithioate

Chemical Property of S,S-diphenyl N²-(4,4',4''-trimethoxytrityl)-2',3'-O-methoxymethyleneguanosine 5'-phosphorodithioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S,S-diphenyl N²-(4,4',4''-trimethoxytrityl)-2',3'-O-methoxymethyleneguanosine 5'-phosphorodithioate

There total 6 articles about S,S-diphenyl N²-(4,4',4''-trimethoxytrityl)-2',3'-O-methoxymethyleneguanosine 5'-phosphorodithioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

cyclohexylammonium S,S-diphenylphosphorodithioate + 2',3'-O-methoxymethylene-N2-(4,4',4''-trimethoxytrityl)guanosine (118533-06-5) → S,S-diphenyl N2-(4,4',4''-trimethoxytrityl)-2',3'-O-methoxymethyleneguanosine 5'-phosphorodithioate (118573-14-1)

Guidance literature:

With 1H-tetrazole; 2,4,5,6-tetramethylbenzenedisulfonyl dichloride; In pyridine; for 0.5h;

DOI:10.1016/0040-4039(88)85060-3

Reference yield: 77.0%

cyclohexylammonium S,S-diphenylphosphorodithioate + 2',3'-O-methoxymethylene-N2-(4,4',4''-trimethoxytrityl)guanosine (118533-06-5) → S,S-diphenyl N2-(4,4',4''-trimethoxytrityl)-2',3'-O-methoxymethyleneguanosine 5'-phosphorodithioate (118573-14-1)

Guidance literature:

With 1H-tetrazole; 1,2,3,5-tetramethylbenzenedisulphonyl dichloride; In pyridine; for 0.5h;

Reference yield:

5'-O-acetyl-2',3'-O-methoxymethylene-N2-(4,4',4''-trimethoxytrityl)guanosine (118533-05-4) → S,S-diphenyl N2-(4,4',4''-trimethoxytrityl)-2',3'-O-methoxymethyleneguanosine 5'-phosphorodithioate (118573-14-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / butylamine-MeOH / 6 h / Ambient temperature

2: 77 percent / 1H-tetrazole, 1,2,3,5-tetramethylbenzenedisulphonyl dichloride / pyridine / 0.5 h

With 1H-tetrazole; 1,2,3,5-tetramethylbenzenedisulphonyl dichloride; butylamine-MeOH; In pyridine;

upstream raw materials:

2',3'-O-methoxymethylene-N²-(4,4',4''-trimethoxytrityl)guanosine

Acetic acid (3aR,4R,6R,6aR)-6-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-2-methoxy-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

5'-O-acetyl-2',3'-O-methoxymethylene-N²-(4,4',4''-trimethoxytrityl)guanosine

2',3',5'-tri-O-acetyl-guanosine

Downstream raw materials:

S-phenyl N²-(4,4',4''-trimethoxytrityl)-2',3'-O-methoxymethylene-7-methylguanosine 5'-phosphorothioate

2',3'-O-methoxymethylene-N²-(4,4',4''-trimethoxytrityl)-7-methylguanosine-5'-diphosphate