(R)-7-bromo-4-((1-cyclobutylethyl)amino)-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

Base Information

Chemical Name:(R)-7-bromo-4-((1-cyclobutylethyl)amino)-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile
CAS No.:1616434-20-8
Molecular Formula:C₂₁H₁₉BrF₃N₅
Molecular Weight:478.315
Hs Code.:

Synonyms:(R)-7-bromo-4-((1-cyclobutylethyl)amino)-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

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Chemical Property of (R)-7-bromo-4-((1-cyclobutylethyl)amino)-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

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Technology Process of (R)-7-bromo-4-((1-cyclobutylethyl)amino)-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

There total 9 articles about (R)-7-bromo-4-((1-cyclobutylethyl)amino)-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616434-19-5
(R)-4-((1-cyclobutylethyl)amino)-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

: 1616434-20-8
(R)-7-bromo-4-((1-cyclobutylethyl)amino)-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

Guidance literature:: With N-Bromosuccinimide; In chloroform; at 20 - 45 ℃; for 1h; Inert atmosphere; Sealed tube;

Reference yield:

: 402-49-3
4-bromomethyltrifluoromethylbenzene

: 1616434-20-8
(R)-7-bromo-4-((1-cyclobutylethyl)amino)-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl acetamide / 2 h / 20 °C

2.1: potassium fluoride / N,N-dimethyl acetamide / 0.08 h / 20 °C

2.2: 120 °C

3.1: bis(η3-allyl-μ-chloropalladium(II)) / N,N-dimethyl acetamide / 120 °C / Inert atmosphere

4.1: N-Bromosuccinimide / chloroform / 1 h / 20 - 45 °C / Inert atmosphere; Sealed tube

With potassium fluoride; N-Bromosuccinimide; bis(η3-allyl-μ-chloropalladium(II)); caesium carbonate; In chloroform; N,N-dimethyl acetamide;

Reference yield:

: 677743-79-2,1355969-30-0
(1R)-1-cyclobutylethan-1-amine hydrogen chloride salt

: 1616434-20-8
(R)-7-bromo-4-((1-cyclobutylethyl)amino)-3-(4-(trifluoromethyl)benzyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium fluoride / N,N-dimethyl acetamide / 0.08 h / 20 °C

1.2: 120 °C

2.1: bis(η3-allyl-μ-chloropalladium(II)) / N,N-dimethyl acetamide / 120 °C / Inert atmosphere

3.1: N-Bromosuccinimide / chloroform / 1 h / 20 - 45 °C / Inert atmosphere; Sealed tube

With potassium fluoride; N-Bromosuccinimide; bis(η3-allyl-μ-chloropalladium(II)); In chloroform; N,N-dimethyl acetamide;