Technology Process of (E)-3'-tert-butoxycarbonylamino-4'-iodocinnamic acid
There total 13 articles about (E)-3'-tert-butoxycarbonylamino-4'-iodocinnamic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium hydroxide;
In
methanol; water;
at 20 ℃;
for 36h;
DOI:10.1071/CH06324
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 100 percent / hydrogen / platinum(IV) oxide / ethyl acetate / 4.5 h
2.1: nitrogen tetroxide / acetonitrile / 1.25 h / -20 °C
3.1: sodium iodide / acetonitrile / -20 - 20 °C
4.1: 92 percent / trifluoroacetic acid / CH2Cl2 / 23 h / 20 °C
5.1: 72 percent / nitric acid / 3.5 h / 0 °C
6.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C
6.2: 82 percent / tetrahydrofuran / 2 h / -78 - 0 °C
7.1: 85 percent / iron; acetic acid / ethanol / 4.5 h / Heating
8.1: 87 percent / sodium hexamethyldisilazide / tetrahydrofuran / -78 - -60 °C
9.1: 98 percent / lithium hydroxide / methanol; H2O / 36 h / 20 °C
With
lithium hydroxide; n-butyllithium; hydrogen; nitric acid; sodium hexamethyldisilazane; dinitrogen tetraoxide; iron; acetic acid; trifluoroacetic acid; sodium iodide;
platinum(IV) oxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; acetonitrile;
6.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1071/CH06324
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 94 percent / toluenesulfonic acid / toluene / Heating
2.1: 100 percent / hydrogen / platinum(IV) oxide / ethyl acetate / 4.5 h
3.1: nitrogen tetroxide / acetonitrile / 1.25 h / -20 °C
4.1: sodium iodide / acetonitrile / -20 - 20 °C
5.1: 92 percent / trifluoroacetic acid / CH2Cl2 / 23 h / 20 °C
6.1: 72 percent / nitric acid / 3.5 h / 0 °C
7.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C
7.2: 82 percent / tetrahydrofuran / 2 h / -78 - 0 °C
8.1: 85 percent / iron; acetic acid / ethanol / 4.5 h / Heating
9.1: 87 percent / sodium hexamethyldisilazide / tetrahydrofuran / -78 - -60 °C
10.1: 98 percent / lithium hydroxide / methanol; H2O / 36 h / 20 °C
With
lithium hydroxide; n-butyllithium; o-toluenesulfonic acid; hydrogen; nitric acid; sodium hexamethyldisilazane; dinitrogen tetraoxide; iron; acetic acid; trifluoroacetic acid; sodium iodide;
platinum(IV) oxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; toluene; acetonitrile;
7.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1071/CH06324
