methyl (E)-3'-nitro-4'-iodocinnamate

Base Information Edit

Chemical Name:methyl (E)-3'-nitro-4'-iodocinnamate
CAS No.:949161-94-8
Molecular Formula:C₁₀H₈INO₄
Molecular Weight:333.082
Hs Code.:
Mol file:949161-94-8.mol

Synonyms:methyl (E)-3'-nitro-4'-iodocinnamate

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Chemical Property of methyl (E)-3'-nitro-4'-iodocinnamate Edit

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Technology Process of methyl (E)-3'-nitro-4'-iodocinnamate

There total 10 articles about methyl (E)-3'-nitro-4'-iodocinnamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1067-74-9
Methyl diethylphosphonoacetate

: 101420-88-6
4-iodo-3-nitrobenzaldehyde

: 949161-94-8
methyl (E)-3'-nitro-4'-iodocinnamate

Guidance literature:: Methyl diethylphosphonoacetate; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

4-iodo-3-nitrobenzaldehyde; In tetrahydrofuran; at -78 - 0 ℃; for 2h;
DOI:10.1071/CH06324

Reference yield: 79.0%

: 101420-88-6
4-iodo-3-nitrobenzaldehyde

: 21204-67-1,2605-67-6
methyl (triphenylphosphoranylidene)acetate

: methyl (Z)-3'-nitro-4'-iodocinnamate

: 949161-94-8
methyl (E)-3'-nitro-4'-iodocinnamate

Guidance literature:: In dichloromethane; at 20 ℃;
DOI:10.1071/CH06324

Reference yield:

: 838-42-6
5,5-dimethyl-2-(4-nitro-phenyl)-[1,3]dioxane

: 949161-94-8
methyl (E)-3'-nitro-4'-iodocinnamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 100 percent / hydrogen / platinum(IV) oxide / ethyl acetate / 4.5 h

2.1: nitrogen tetroxide / acetonitrile / 1.25 h / -20 °C

3.1: sodium iodide / acetonitrile / -20 - 20 °C

4.1: 92 percent / trifluoroacetic acid / CH₂Cl₂ / 23 h / 20 °C

5.1: 72 percent / nitric acid / 3.5 h / 0 °C

6.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

6.2: 82 percent / tetrahydrofuran / 2 h / -78 - 0 °C

With n-butyllithium; hydrogen; nitric acid; dinitrogen tetraoxide; trifluoroacetic acid; sodium iodide; platinum(IV) oxide; In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile; 6.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1071/CH06324