4-methyl-5(R)-<1-((1,1-dimethylethyl)dimethylsilyloxy)-2(R)-propyl>-3-cyclohexen-1(S)-ol

Base Information

Chemical Name:4-methyl-5(R)-<1-((1,1-dimethylethyl)dimethylsilyloxy)-2(R)-propyl>-3-cyclohexen-1(S)-ol
CAS No.:112320-97-5
Molecular Formula:C₁₆H₃₂O₂Si
Molecular Weight:284.514
Hs Code.:

Synonyms:4-methyl-5(R)-<1-((1,1-dimethylethyl)dimethylsilyloxy)-2(R)-propyl>-3-cyclohexen-1(S)-ol

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Chemical Property of 4-methyl-5(R)-<1-((1,1-dimethylethyl)dimethylsilyloxy)-2(R)-propyl>-3-cyclohexen-1(S)-ol

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Technology Process of 4-methyl-5(R)-<1-((1,1-dimethylethyl)dimethylsilyloxy)-2(R)-propyl>-3-cyclohexen-1(S)-ol

There total 14 articles about 4-methyl-5(R)-<1-((1,1-dimethylethyl)dimethylsilyloxy)-2(R)-propyl>-3-cyclohexen-1(S)-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 112321-04-7
4-methyl-5(R)-<1-(((1,1-dimethylethyl)dimethylsilyl)oxy)-2(R)-propyl>-3-cyclohexen-1(S)-yl acetate

: 112320-97-5
4-methyl-5(R)-<1-((1,1-dimethylethyl)dimethylsilyloxy)-2(R)-propyl>-3-cyclohexen-1(S)-ol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 1h;
DOI:10.1021/jo00238a030

Reference yield: 7.0%

: 112321-08-1
2(R)-<2-methyl-5(S)-hydroxy-2-cyclohexen-1(R)-yl>propan-1-ol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 112320-97-5
4-methyl-5(R)-<1-((1,1-dimethylethyl)dimethylsilyloxy)-2(R)-propyl>-3-cyclohexen-1(S)-ol

: 112321-28-5
1-methyl-4(S)-<((1,1-dimethylethyl)dimethylsilyl)oxy>-6(R)-<1-(((1,1-dimethylethyl)dimethylsilyl)oxy)-2(R)-propyl>-1-cyclohexene

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 15h; Ambient temperature;
DOI:10.1021/jo00238a030

Reference yield:

: 112321-00-3,112419-70-2
2-((1R,5S)-5-Isopropenyl-2-methyl-cyclohex-2-enyl)-propan-1-ol

: 112320-97-5
4-methyl-5(R)-<1-((1,1-dimethylethyl)dimethylsilyloxy)-2(R)-propyl>-3-cyclohexen-1(S)-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / N-bromosuccinimide / acetone / 0.25 h / 0 °C

2: O₃ / CH₂Cl₂ / 0.2 h / -78 °C

3: acetic anhydride, Et₃N, (N,N-dimethylamino)pyridine / CH₂Cl₂ / 16 h / 40 °C

4: 7 percent / zinc / ethanol; H₂O / 16 h / Heating

5: 83 percent / Et₃N, DMAP / CH₂Cl₂ / 15 h / Ambient temperature

With dmap; N-Bromosuccinimide; acetic anhydride; ozone; triethylamine; zinc; In ethanol; dichloromethane; water; acetone;
DOI:10.1021/jo00238a030