(S)-methyl-2-methyl-2-(2-(pyrrolidine-2-carboxamido)benzamido)propanoate

Base Information

Chemical Name:(S)-methyl-2-methyl-2-(2-(pyrrolidine-2-carboxamido)benzamido)propanoate
CAS No.:1425940-84-6
Molecular Formula:C₁₇H₂₃N₃O₄
Molecular Weight:333.387
Hs Code.:

Synonyms:(S)-methyl-2-methyl-2-(2-(pyrrolidine-2-carboxamido)benzamido)propanoate

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Chemical Property of (S)-methyl-2-methyl-2-(2-(pyrrolidine-2-carboxamido)benzamido)propanoate

Chemical Property:

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Technology Process of (S)-methyl-2-methyl-2-(2-(pyrrolidine-2-carboxamido)benzamido)propanoate

There total 5 articles about (S)-methyl-2-methyl-2-(2-(pyrrolidine-2-carboxamido)benzamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1425940-82-4
C₂₂H₃₁N₃O₆

: 1425940-84-6
(S)-methyl-2-methyl-2-(2-(pyrrolidine-2-carboxamido)benzamido)propanoate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/ol4002762

Reference yield:

: 221539-54-4
N-(2-aminobenzoyl)-α-methylalanine methyl ester

: 1425940-84-6
(S)-methyl-2-methyl-2-(2-(pyrrolidine-2-carboxamido)benzamido)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0.42 h / 0 °C / Inert atmosphere

1.2: 8 h / Inert atmosphere; Reflux

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With chloroformic acid ethyl ester; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol4002762

Reference yield:

: 610-14-0
2-nitrobenzyl chloride

: 1425940-84-6
(S)-methyl-2-methyl-2-(2-(pyrrolidine-2-carboxamido)benzamido)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 5 h / 20 °C / Cooling with ice

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 5 h / 3102.97 Torr

3.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0.42 h / 0 °C / Inert atmosphere

3.2: 8 h / Inert atmosphere; Reflux

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With palladium 10% on activated carbon; hydrogen; chloroformic acid ethyl ester; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/ol4002762