4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-carbamoyloxy-1-propenyl>-3-cephem-4-carboxylate

Base Information

Chemical Name:4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-carbamoyloxy-1-propenyl>-3-cephem-4-carboxylate
CAS No.:133731-33-6
Molecular Formula:C₆₂H₅₂N₆O₈S₂
Molecular Weight:1073.26
Hs Code.:

Synonyms:4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-carbamoyloxy-1-propenyl>-3-cephem-4-carboxylate

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Chemical Property of 4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-carbamoyloxy-1-propenyl>-3-cephem-4-carboxylate

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Technology Process of 4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-carbamoyloxy-1-propenyl>-3-cephem-4-carboxylate

There total 7 articles about 4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-carbamoyloxy-1-propenyl>-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1189-71-5
isocyanate de chlorosulfonyle

: 133731-50-7
4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-hydroxy-1-propenyl>-3-cephem-4-carboxylate

: 133731-33-6
4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-carbamoyloxy-1-propenyl>-3-cephem-4-carboxylate

Guidance literature:: In tetrahydrofuran; at -20 ℃; for 1h;
DOI:10.7164/antibiotics.47.1526

Reference yield:

: para-methoxybenzyl (6R,7R)-7-amino-3-chloromethyl-3-cephem-4-carboxylate hydrochloride

: 133731-33-6
4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-carbamoyloxy-1-propenyl>-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) 1-hydroxybenzotriazole, DCC, 2.) Et₃N / 1.) DMF, 1 h, 2.) DMF, 18 h

2: NaI / acetone / 1 h

3: ethyl acetate / 4 h

4: 1.) 1M NaOH / 1.) CH₂Cl₂, H₂O, 20 min, 2.) CH₂Cl₂, r.t., 16 h

5: 49 percent / 1M HCl / acetone / 2 h / Ambient temperature

6: 99 percent / tetrahydrofuran / 1 h / -20 °C

With hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; sodium iodide; In tetrahydrofuran; ethyl acetate; acetone;
DOI:10.7164/antibiotics.47.1526

Reference yield:

: 4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-(triphenylphosphonium)methyl-3-cephem-4-carboxylate iodide

: 133731-33-6
4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-carbamoyloxy-1-propenyl>-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 1M NaOH / 1.) CH₂Cl₂, H₂O, 20 min, 2.) CH₂Cl₂, r.t., 16 h

2: 49 percent / 1M HCl / acetone / 2 h / Ambient temperature

3: 99 percent / tetrahydrofuran / 1 h / -20 °C

With hydrogenchloride; sodium hydroxide; In tetrahydrofuran; acetone;
DOI:10.7164/antibiotics.47.1526