1-tert-butyldimethylsilyloxymethyl-3-(2,3,4-trimethoxy-6-methoxycarbonylphenoxy)-4,8,9,10-tetra methoxydibenzo[b,d]pyran-6-one

Base Information

Chemical Name:1-tert-butyldimethylsilyloxymethyl-3-(2,3,4-trimethoxy-6-methoxycarbonylphenoxy)-4,8,9,10-tetra methoxydibenzo[b,d]pyran-6-one
CAS No.:1242690-43-2
Molecular Formula:C₃₅H₄₄O₁₃Si
Molecular Weight:700.812
Hs Code.:

Synonyms:1-tert-butyldimethylsilyloxymethyl-3-(2,3,4-trimethoxy-6-methoxycarbonylphenoxy)-4,8,9,10-tetra methoxydibenzo[b,d]pyran-6-one

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Chemical Property of 1-tert-butyldimethylsilyloxymethyl-3-(2,3,4-trimethoxy-6-methoxycarbonylphenoxy)-4,8,9,10-tetra methoxydibenzo[b,d]pyran-6-one

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Technology Process of 1-tert-butyldimethylsilyloxymethyl-3-(2,3,4-trimethoxy-6-methoxycarbonylphenoxy)-4,8,9,10-tetra methoxydibenzo[b,d]pyran-6-one

There total 11 articles about 1-tert-butyldimethylsilyloxymethyl-3-(2,3,4-trimethoxy-6-methoxycarbonylphenoxy)-4,8,9,10-tetra methoxydibenzo[b,d]pyran-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1242690-41-0
5-tert-butyldimethylsilyloxymethyl-2-methoxy-3-(2,3,4-trimethoxy-6-methoxycarbonylphenoxy)-phenyl-2-iodo-3,4,5-trimethoxybenzoate

: 1242690-43-2
1-tert-butyldimethylsilyloxymethyl-3-(2,3,4-trimethoxy-6-methoxycarbonylphenoxy)-4,8,9,10-tetra methoxydibenzo[b,d]pyran-6-one

Guidance literature:: With sodium acetate; palladium diacetate; triphenylphosphine; In N,N-dimethyl acetamide; at 120 ℃; for 1.33333h;
DOI:10.1248/cpb.58.435

Reference yield:

: 1242690-38-5
methyl 2-(3-hydroxy-5-hydroxymethyl-2-methoxyphenoxy)-3,4,5-trimethoxybenzoate

: 1242690-43-2
1-tert-butyldimethylsilyloxymethyl-3-(2,3,4-trimethoxy-6-methoxycarbonylphenoxy)-4,8,9,10-tetra methoxydibenzo[b,d]pyran-6-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / dichloromethane / 10 h / 20 °C / Inert atmosphere

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C / Inert atmosphere

3: sodium acetate; palladium diacetate; triphenylphosphine / N,N-dimethyl acetamide / 1.33 h / 120 °C / Inert atmosphere

With 1H-imidazole; dmap; sodium acetate; palladium diacetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In dichloromethane; N,N-dimethyl acetamide;
DOI:10.1016/j.tet.2011.01.004

Reference yield:

: 1242690-36-3
3-benzyloxy-5-hydroxy-4-methoxybenzaldehyde

: 1242690-43-2
1-tert-butyldimethylsilyloxymethyl-3-(2,3,4-trimethoxy-6-methoxycarbonylphenoxy)-4,8,9,10-tetra methoxydibenzo[b,d]pyran-6-one

Guidance literature:: Multi-step reaction with 6 steps

1: copper / N,N-dimethyl-formamide / 1 h / 200 °C / Inert atmosphere

2: sodium tetrahydroborate / methanol / 0.5 h / 20 - 40 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr

4: 1H-imidazole / dichloromethane / 10 h / 20 °C / Inert atmosphere

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C / Inert atmosphere

6: sodium acetate; palladium diacetate; triphenylphosphine / N,N-dimethyl acetamide / 1.33 h / 120 °C / Inert atmosphere

With 1H-imidazole; dmap; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; sodium acetate; palladium diacetate; copper; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In methanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; 1: Ullmann condensation;
DOI:10.1016/j.tet.2011.01.004