5-tert-butyldimethylsilyloxymethyl-2-methoxy-3-(2,3,4-trimethoxy-6-methoxycarbonylphenoxy)-phenyl-2-iodo-3,4,5-trimethoxybenzoate

Base Information

Chemical Name:5-tert-butyldimethylsilyloxymethyl-2-methoxy-3-(2,3,4-trimethoxy-6-methoxycarbonylphenoxy)-phenyl-2-iodo-3,4,5-trimethoxybenzoate
CAS No.:1242690-41-0
Molecular Formula:C₃₅H₄₅IO₁₃Si
Molecular Weight:828.725
Hs Code.:

Synonyms:5-tert-butyldimethylsilyloxymethyl-2-methoxy-3-(2,3,4-trimethoxy-6-methoxycarbonylphenoxy)-phenyl-2-iodo-3,4,5-trimethoxybenzoate

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Chemical Property of 5-tert-butyldimethylsilyloxymethyl-2-methoxy-3-(2,3,4-trimethoxy-6-methoxycarbonylphenoxy)-phenyl-2-iodo-3,4,5-trimethoxybenzoate

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Technology Process of 5-tert-butyldimethylsilyloxymethyl-2-methoxy-3-(2,3,4-trimethoxy-6-methoxycarbonylphenoxy)-phenyl-2-iodo-3,4,5-trimethoxybenzoate

There total 9 articles about 5-tert-butyldimethylsilyloxymethyl-2-methoxy-3-(2,3,4-trimethoxy-6-methoxycarbonylphenoxy)-phenyl-2-iodo-3,4,5-trimethoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1242690-29-4
methyl 2-(5-tert-butyldimethylsilyloxymethyl-3-hydroxy-2-methoxyphenoxy)-3,4,5-trimethoxybenzoate

: 98799-41-8
2-iodo-3,4,5-trimethoxybenzoic acid

: 1242690-41-0
5-tert-butyldimethylsilyloxymethyl-2-methoxy-3-(2,3,4-trimethoxy-6-methoxycarbonylphenoxy)-phenyl-2-iodo-3,4,5-trimethoxybenzoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.tet.2011.01.004

Reference yield:

: 1242690-38-5
methyl 2-(3-hydroxy-5-hydroxymethyl-2-methoxyphenoxy)-3,4,5-trimethoxybenzoate

: 1242690-41-0
5-tert-butyldimethylsilyloxymethyl-2-methoxy-3-(2,3,4-trimethoxy-6-methoxycarbonylphenoxy)-phenyl-2-iodo-3,4,5-trimethoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / dichloromethane / 10 h / 20 °C / Inert atmosphere

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C / Inert atmosphere

With 1H-imidazole; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/j.tet.2011.01.004

Reference yield:

: 1242690-36-3
3-benzyloxy-5-hydroxy-4-methoxybenzaldehyde

: 1242690-41-0
5-tert-butyldimethylsilyloxymethyl-2-methoxy-3-(2,3,4-trimethoxy-6-methoxycarbonylphenoxy)-phenyl-2-iodo-3,4,5-trimethoxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: copper / N,N-dimethyl-formamide / 1 h / 200 °C / Inert atmosphere

2: sodium tetrahydroborate / methanol / 0.5 h / 20 - 40 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr

4: 1H-imidazole / dichloromethane / 10 h / 20 °C / Inert atmosphere

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C / Inert atmosphere

With 1H-imidazole; dmap; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; copper; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; N,N-dimethyl-formamide; 1: Ullmann condensation;
DOI:10.1016/j.tet.2011.01.004