(2R,3R,4S)-(-)-N-tert-butoxycarbonyl-3,4-dihydroxy-2-phenyl-pyrrolidine isopropylidene acetal

Base Information

Chemical Name:(2R,3R,4S)-(-)-N-tert-butoxycarbonyl-3,4-dihydroxy-2-phenyl-pyrrolidine isopropylidene acetal
CAS No.:474558-83-3
Molecular Formula:C₁₈H₂₅NO₄
Molecular Weight:319.401
Hs Code.:

Synonyms:(2R,3R,4S)-(-)-N-tert-butoxycarbonyl-3,4-dihydroxy-2-phenyl-pyrrolidine isopropylidene acetal

Suppliers and Price of (2R,3R,4S)-(-)-N-tert-butoxycarbonyl-3,4-dihydroxy-2-phenyl-pyrrolidine isopropylidene acetal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3R,4S)-(-)-N-tert-butoxycarbonyl-3,4-dihydroxy-2-phenyl-pyrrolidine isopropylidene acetal

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3R,4S)-(-)-N-tert-butoxycarbonyl-3,4-dihydroxy-2-phenyl-pyrrolidine isopropylidene acetal

There total 14 articles about (2R,3R,4S)-(-)-N-tert-butoxycarbonyl-3,4-dihydroxy-2-phenyl-pyrrolidine isopropylidene acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 77-76-9
2,2-dimethoxy-propane

: 474558-82-2
(2R,3R,4S)-N-tert-butoxycarbonyl-3,4-dihydroxy-2-phenylpyrrolidine

: 474558-83-3
(2R,3R,4S)-(-)-N-tert-butoxycarbonyl-3,4-dihydroxy-2-phenyl-pyrrolidine isopropylidene acetal

Guidance literature:: With toluene-4-sulfonic acid; In acetone; for 3h;
DOI:10.1021/jo025832p

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 474558-83-3
(2R,3R,4S)-(-)-N-tert-butoxycarbonyl-3,4-dihydroxy-2-phenyl-pyrrolidine isopropylidene acetal

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / NaHCO₃ / methanol / 12 h / ultrasonic irradiation

2: 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / 0 °C

3: 0.86 g / 1,3-dimethyl-2-phenyl[1,3,2]diazaphospholidine / 24 h / 65 °C

4: 99 percent / (bis(tricyclohexyl)phosphine)ruthenium(II) dichloride / CH₂Cl₂ / 1 h / 20 °C

5: 99 percent / OsO₄; K₂Fe(CN)6; K₂CO₃ / H₂O; 2-methyl-propan-2-ol / 24 h / 20 °C

6: 96 percent / p-TsOH*H₂O / acetone / 3 h

With 1,3-dimethyl-2-phenyl-1,3,2-diazaphospholidine; dmap; osmium(VIII) oxide; K₂Fe(CN)6; sodium hydrogencarbonate; potassium carbonate; toluene-4-sulfonic acid; (bis(tricyclohexyl)phosphine)ruthenium(II) dichloride; In methanol; dichloromethane; water; acetone; tert-butyl alcohol;
DOI:10.1021/jo025832p

Reference yield:

: 21915-53-7,40641-81-4,98819-67-1,98819-68-2,99528-63-9,104196-23-8,105663-44-3,116661-35-9,91465-28-0
(2R,3S)-(3-phenyloxiran-2-yl)methanol

: 474558-83-3
(2R,3R,4S)-(-)-N-tert-butoxycarbonyl-3,4-dihydroxy-2-phenyl-pyrrolidine isopropylidene acetal

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / titanium tetraisopropoxide / CH₂Cl₂ / 8 h / 65 °C

2: 95 percent / NaHCO₃ / methanol / 12 h / ultrasonic irradiation

3: 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / 0 °C

4: 0.86 g / 1,3-dimethyl-2-phenyl[1,3,2]diazaphospholidine / 24 h / 65 °C

5: 99 percent / (bis(tricyclohexyl)phosphine)ruthenium(II) dichloride / CH₂Cl₂ / 1 h / 20 °C

6: 99 percent / OsO₄; K₂Fe(CN)6; K₂CO₃ / H₂O; 2-methyl-propan-2-ol / 24 h / 20 °C

7: 96 percent / p-TsOH*H₂O / acetone / 3 h

With 1,3-dimethyl-2-phenyl-1,3,2-diazaphospholidine; titanium(IV) isopropylate; dmap; osmium(VIII) oxide; K₂Fe(CN)6; sodium hydrogencarbonate; potassium carbonate; toluene-4-sulfonic acid; (bis(tricyclohexyl)phosphine)ruthenium(II) dichloride; In methanol; dichloromethane; water; acetone; tert-butyl alcohol;
DOI:10.1021/jo025832p