(E)-(2R,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-5-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-3-methyl-hex-3-enal

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Chemical Name:(E)-(2R,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-5-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-3-methyl-hex-3-enal
CAS No.:164592-62-5
Molecular Formula:C₄₆H₈₂O₆S₂Si₂
Molecular Weight:851.456
Hs Code.:

(E)-(2R,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-5-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-3-methyl-hex-3-enal

Synonyms:(E)-(2R,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-5-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-3-methyl-hex-3-enal

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Chemical Property of (E)-(2R,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-5-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-3-methyl-hex-3-enal

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Technology Process of (E)-(2R,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-5-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-3-methyl-hex-3-enal

There total 18 articles about (E)-(2R,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-5-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-3-methyl-hex-3-enal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 186449-16-1
2-[(E)-(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-5,5-dimethoxy-1,3-dimethyl-pent-2-enyl]-2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithiane

: 164592-62-5
(E)-(2R,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-5-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-3-methyl-hex-3-enal

Guidance literature:: With trichloroacetic acid; In acetone;
DOI:10.1021/ja00124a043

Reference yield:

: 157837-41-7
{(1R,2R,4S)-4-[(2R,3R)-4-Iodo-3-(4-methoxy-benzyloxy)-2-methyl-butyl]-2-methoxy-cyclohexyloxy}-triisopropyl-silane

: 164592-62-5
(E)-(2R,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-5-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-3-methyl-hex-3-enal

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / t-BuLi / hexamethylphosphoric acid triamide; tetrahydrofuran; pentane / -78 °C

2: 70 percent / Cl₃CCO₂H / acetone / Ambient temperature

With tert.-butyl lithium; trichloroacetic acid; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; acetone; pentane;
DOI:10.1021/ja963066w

Reference yield:

: 164592-61-4
tert-Butyl-((E)-(1R,4R)-1-dimethoxymethyl-4-[1,3]dithian-2-yl-2-methyl-pent-2-enyloxy)-dimethyl-silane

: 164592-62-5
(E)-(2R,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-5-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-3-methyl-hex-3-enal

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / t-BuLi / hexamethylphosphoric acid triamide; tetrahydrofuran; pentane / -78 °C

2: 70 percent / Cl₃CCO₂H / acetone / Ambient temperature

With tert.-butyl lithium; trichloroacetic acid; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; acetone; pentane;
DOI:10.1021/ja963066w