2-[(E)-(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-5,5-dimethoxy-1,3-dimethyl-pent-2-enyl]-2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithiane

Base Information

Chemical Name:2-[(E)-(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-5,5-dimethoxy-1,3-dimethyl-pent-2-enyl]-2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithiane
CAS No.:186449-16-1
Molecular Formula:C₄₈H₈₈O₇S₂Si₂
Molecular Weight:897.526
Hs Code.:

2-[(E)-(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-5,5-dimethoxy-1,3-dimethyl-pent-2-enyl]-2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithiane

Synonyms:2-[(E)-(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-5,5-dimethoxy-1,3-dimethyl-pent-2-enyl]-2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithiane

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Chemical Property of 2-[(E)-(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-5,5-dimethoxy-1,3-dimethyl-pent-2-enyl]-2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithiane

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Technology Process of 2-[(E)-(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-5,5-dimethoxy-1,3-dimethyl-pent-2-enyl]-2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithiane

There total 16 articles about 2-[(E)-(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-5,5-dimethoxy-1,3-dimethyl-pent-2-enyl]-2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithiane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 157837-41-7
{(1R,2R,4S)-4-[(2R,3R)-4-Iodo-3-(4-methoxy-benzyloxy)-2-methyl-butyl]-2-methoxy-cyclohexyloxy}-triisopropyl-silane

: 164592-61-4
tert-Butyl-((E)-(1R,4R)-1-dimethoxymethyl-4-[1,3]dithian-2-yl-2-methyl-pent-2-enyloxy)-dimethyl-silane

: 186449-16-1
2-[(E)-(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-5,5-dimethoxy-1,3-dimethyl-pent-2-enyl]-2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithiane

Guidance literature:: With tert.-butyl lithium; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/ja00124a043

Reference yield:

: 127258-23-5
(1R,2R,4R)-4-<(phenylsulfonyl)methyl>-2-methoxy-1-<oxy>cyclohexane

: 186449-16-1
2-[(E)-(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-5,5-dimethoxy-1,3-dimethyl-pent-2-enyl]-2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithiane

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-BuLi, 2.) BF₃*Et₂O, 3.) Na₂HPO₄, 4.) Na(Hg)

2: 92 percent / Et₃N

3: 87 percent / NaH / hexamethylphosphoric acid triamide / 6 h / Ambient temperature

4: 78 percent / LiI, BF₃*OEt₂ / diethyl ether / -78 °C

5: 84 percent / BF₃*Et₂O / CH₂Cl₂ / -78 °C

6: 91 percent / t-BuLi / hexamethylphosphoric acid triamide; tetrahydrofuran; pentane / -78 °C

With disodium hydrogenphosphate; n-butyllithium; sodium amalgam; boron trifluoride diethyl etherate; tert.-butyl lithium; sodium hydride; triethylamine; lithium iodide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; pentane;
DOI:10.1021/ja963066w

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 186449-16-1
2-[(E)-(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-5,5-dimethoxy-1,3-dimethyl-pent-2-enyl]-2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithiane

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / BF₃*Et₂O / CH₂Cl₂ / -78 °C

2: 91 percent / t-BuLi / hexamethylphosphoric acid triamide; tetrahydrofuran; pentane / -78 °C

With boron trifluoride diethyl etherate; tert.-butyl lithium; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; pentane;
DOI:10.1021/ja963066w