3-tert-butyl-4-phenyl-3-cyclobutene-1,2-dione 2-(ethylene acetal)

Base Information

• Chemical Name: 3-tert-butyl-4-phenyl-3-cyclobutene-1,2-dione 2-(ethylene acetal)
• CAS No.: 128242-73-9
• Molecular Formula: C₁₆H₁₈O₃
• Molecular Weight: 258.317
• Mol file: 128242-73-9.mol

Synonyms:3-tert-butyl-4-phenyl-3-cyclobutene-1,2-dione 2-(ethylene acetal)

Chemical Property of 3-tert-butyl-4-phenyl-3-cyclobutene-1,2-dione 2-(ethylene acetal)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-tert-butyl-4-phenyl-3-cyclobutene-1,2-dione 2-(ethylene acetal)

There total 4 articles about 3-tert-butyl-4-phenyl-3-cyclobutene-1,2-dione 2-(ethylene acetal) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.8%

4-tert-butyl-4-hydroxy-2-isopropoxy-3-phenyl-2-cyclobutenone ethylene acetal (128242-57-9) → 3-tert-butyl-4-phenyl-3-cyclobutene-1,2-dione 2-(ethylene acetal) (128242-73-9)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 0.166667h; Ambient temperature;

DOI:10.1021/jo00306a011

Reference yield:

2,3-diisopropoxy-4-phenyl-4-(trimethylsiloxy)-2-cyclobuten-1-one (128242-38-6) → 3-tert-butyl-4-phenyl-3-cyclobutene-1,2-dione 2-(ethylene acetal) (128242-73-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / trimethylsilyl triflate / tetrahydrofuran / 6 h

2: 97 percent / tetrahydrofuran; diethyl ether / 0.08 h / -78 °C

3: 99.8 percent / 2N HCl / tetrahydrofuran / 0.17 h / Ambient temperature

With hydrogenchloride; trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jo00306a011

Reference yield:

2,3-bis(1-methylethoxy)-4-hydroxy-4-phenylcyclobut-2-en-1-one (114094-64-3) → 3-tert-butyl-4-phenyl-3-cyclobutene-1,2-dione 2-(ethylene acetal) (128242-73-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / NEt₃ / diethyl ether / 12 h

2: 80 percent / trimethylsilyl triflate / tetrahydrofuran / 6 h

3: 97 percent / tetrahydrofuran; diethyl ether / 0.08 h / -78 °C

4: 99.8 percent / 2N HCl / tetrahydrofuran / 0.17 h / Ambient temperature

With hydrogenchloride; triethylamine; trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jo00306a011

upstream raw materials:

4-tert-butyl-4-hydroxy-2-isopropoxy-3-phenyl-2-cyclobutenone ethylene acetal

2,3-bis(1-methylethoxy)-4-hydroxy-4-phenylcyclobut-2-en-1-one

3-(1-methylethoxy)-4-phenyl-3-cyclobutene-1,2-dione 2-ethylene acetal

2,3-diisopropoxy-4-phenyl-4-(trimethylsiloxy)-2-cyclobuten-1-one