114094-64-3

Upstream product

• 61699-62-5 diisopropyl squarate 
• 591-51-5 phenyllithium 
• 108-86-1 bromobenzene 

Downstream Products

• 128242-38-6 2,3-diisopropoxy-4-phenyl-4-(trimethylsiloxy)-2-cyclobuten-1-one 
• 128242-73-9 3-tert-butyl-4-phenyl-3-cyclobutene-1,2-dione 2-(ethylene acetal) 
• 128242-44-4 3-(1-methylethoxy)-4-phenyl-3-cyclobutene-1,2-dione 2-ethylene acetal 
• 128242-74-0 3-(1-hexynyl)-4-phenyl-3-cyclobutene-1,2-dione 2-(ethylene acetal) 
• 128242-57-9 4-tert-butyl-4-hydroxy-2-isopropoxy-3-phenyl-2-cyclobutenone ethylene acetal 
• 128242-58-0 4-(1-hexynyl)-4-hydroxy-2-isopropoxy-3-phenyl-2-cyclobutenone ethylene acetal 
• 114094-71-2 3-isopropoxy-4-phenylcyclobut-3-ene-1,2-dione 

Relevant academic research and scientific papers

Anhydrous proton conductivities of squaric acid derivatives

In this communication, we introduce squaric acid derivatives as anhydrous proton conductors. We report the synthesis, characterization and proton conductivities of four squaric acid derivatives. The anhydrous proton conductivity of one of the derivatives

Synthesis and electro-spectroelectrochemistry of ferrocenyl naphthaquinones

A practical approach to ferrocenyl naphthaquinone derivatives involving thermal rearrangement of variously substituted 4-aryl-4-hydroxycyclobutenones was described. The reaction of 3-ferrocenyl-4-isopropoxy-3-cyclobutene-1,2-dione with different aryl lith

Mn(III)-based oxidative radical ring-expansion reaction using squarate derivatives: Selective synthesis of bis(butenolide)s and the acetate monomers

The Mn(III)-based oxidation of phenyl- and alkyl-substituted hydroxycyclobutenones selectively produced the bis(butenolide)s or the acetate monomers via the 5-endo radical cyclization depending upon the concentration of the reaction. A similar reaction of hydroxycyclobutenones bearing an alkenyl and alkynyl substituent did not produce any bis(butenolide)s or acetate monomers, but the 5-exo and 6-endo radical cyclization products including the unsaturated group. The oxidation of the hydroxycyclobutenones having an unsaturated substituent in the presence of alkenes afforded radical coupling products during the 5-exo radical cyclization. The reaction details, structure determination of the products, and the mechanism for the formation of the products are described.

BISARYLCYCLOBUTENE DERIVATES AS CYCLOOXYGENASE INHIBITORS

The invention encompasses the novel compound of formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).

Bisaryl cyclobutenes derivatives as cyclooxygenase inhibitors

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising

An Improved Method for the Synthesis of Substituted Cyclobutenediones

Practical and high yielding routes to substituted cyclobutenediones are described. 3,4-Bis(1-methylethoxy)cyclobut-3-ene-1,2-dione (diisopropyl squarate), a stable, crystalline derivative of squaric acid, was easily prepared by refluxing squaric acid in 2