2'-Amino-5'-chloro-3'-hydroxy-2,2,2-trifluoroacetophenone

Base Information

Chemical Name:2'-Amino-5'-chloro-3'-hydroxy-2,2,2-trifluoroacetophenone
CAS No.:205756-23-6
Molecular Formula:C₈H₅ClF₃NO₂
Molecular Weight:239.581
Hs Code.:
DSSTox Substance ID:DTXSID701183573

Synonyms:205756-23-6;2'-amino-5'-chloro-3'-hydroxy-2,2,2-trifluoroacetophenone;1-(2-amino-5-chloro-3-hydroxyphenyl)-2,2,2-trifluoroethanone;1-(2-Amino-5-chloro-3-hydroxyphenyl)-2,2,2-trifluoroethan-1-one;starbld0022563;SCHEMBL6990264;DTXSID701183573

Suppliers and Price of 2'-Amino-5'-chloro-3'-hydroxy-2,2,2-trifluoroacetophenone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2'-Amino-5'-chloro-3'-hydroxy-2,2,2-trifluoroacetophenone

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:238.9960906
Heavy Atom Count:15
Complexity:259

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=C(C=C(C(=C1C(=O)C(F)(F)F)N)O)Cl

Technology Process of 2'-Amino-5'-chloro-3'-hydroxy-2,2,2-trifluoroacetophenone

There total 6 articles about 2'-Amino-5'-chloro-3'-hydroxy-2,2,2-trifluoroacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

aqueous Na₂ CO₃: aqueous Na₂ CO₃

: 205756-22-5
2'-amino-5'-chloro-3'-methoxy-2,2,2-trifluoroacetophenone

: 205756-23-6
2'-amino-5'-chloro-3'-hydroxy-2,2,2-trifluoroacetophenone

Guidance literature:: With boron tribromide; In dichloromethane;

Reference yield:

: 205756-22-5
2'-amino-5'-chloro-3'-methoxy-2,2,2-trifluoroacetophenone

: 205756-23-6
2'-amino-5'-chloro-3'-hydroxy-2,2,2-trifluoroacetophenone

Guidance literature:: With boron tribromide; In dichloromethane;
DOI:10.1016/S0960-894X(01)00012-9

Reference yield:

: 6627-53-8
1-chloro-3-methoxy-4-nitrobenzene

: 205756-23-6
2'-amino-5'-chloro-3'-hydroxy-2,2,2-trifluoroacetophenone

Guidance literature:: Multi-step reaction with 5 steps

1: SnCl₂; EtOH / Heating

2: NEt₃ / CH₂Cl₂

3: s-BuLi / tetrahydrofuran / -20 - 0 °C

4: aq. HCl / 1,2-dimethoxy-ethane / Heating

5: BBr₃ / CH₂Cl₂

With hydrogenchloride; ethanol; sec.-butyllithium; boron tribromide; triethylamine; tin(ll) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1016/S0960-894X(01)00012-9