1-<(dimethylamino)carbonyl>-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester

Base Information

Chemical Name:1-<(dimethylamino)carbonyl>-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester
CAS No.:112795-80-9
Molecular Formula:C₁₇H₂₀N₄O₅S
Molecular Weight:392.436
Hs Code.:

Synonyms:1-<(dimethylamino)carbonyl>-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester

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Chemical Property of 1-<(dimethylamino)carbonyl>-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester

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Technology Process of 1-<(dimethylamino)carbonyl>-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester

There total 5 articles about 1-<(dimethylamino)carbonyl>-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123486-07-7
1,6-dihydro-2-[[(4-methoxyphenyl)methyl]thio]-4-methyl-1-[(dimethylamino)carbonyl]-6-(3-nitrophenyl)-5-pyrimidinecarboxylic acid, ethyl ester

: 112795-80-9
1-<(dimethylamino)carbonyl>-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester

Guidance literature:: With trifluoroacetic acid; ethanethiol; In dichloromethane; Yield given; Ambient temperature;
DOI:10.1021/jo00286a020

Reference yield:

: 39562-16-8
ethyl (Z)-2-(3-nitrobenzylidene)-3-oxobutanoate

: 112795-80-9
1-<(dimethylamino)carbonyl>-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / sodium acetate / dimethylformamide / 4 h / 70 °C

2: pyridine / tetrahydrofuran; toluene / 0.5 h / 0 - 5 °C

3: 0.6 g / tetrahydrofuran; toluene; H₂O / 0.5 h / 0 - 5 °C

4: trifluoroacetic acid, ethanethiol / CH₂Cl₂ / Ambient temperature

With pyridine; sodium acetate; trifluoroacetic acid; ethanethiol; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00286a020

Reference yield:

: 106720-60-9
1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid ethyl ester

: 112795-80-9
1-<(dimethylamino)carbonyl>-1,2,3,6-tetrahydro-4-methyl-6-(3-nitrophenyl)-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 41 percent / citric acid / 8 h / 100 °C

2: pyridine / tetrahydrofuran; toluene / 0.5 h / 0 - 5 °C

3: 0.6 g / tetrahydrofuran; toluene; H₂O / 0.5 h / 0 - 5 °C

4: trifluoroacetic acid, ethanethiol / CH₂Cl₂ / Ambient temperature

With pyridine; trifluoroacetic acid; ethanethiol; citric acid; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1021/jo00286a020