1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid ethyl ester

Base Information

• Chemical Name: 1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid ethyl ester
• CAS No.: 106720-60-9
• Molecular Formula: C₁₅H₁₇N₃O₅
• Molecular Weight: 319.317

Synonyms:1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid ethyl ester

Chemical Property of 1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid ethyl ester

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Technology Process of 1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid ethyl ester

There total 1 articles about 1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

ethyl (Z)-2-(3-nitrobenzylidene)-3-oxobutanoate (39562-16-8) + 2-methyl-isourea (2440-60-0) → 1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid ethyl ester (106720-60-9)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 65 ℃;

DOI:10.1021/jm00167a035

Reference yield: 41.0%

1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid ethyl ester (106720-60-9) + p-methoxybenzylmercaptan (6258-60-2) → 1,4-Dihydro-2-[[(4-methoxyphenyl)methyl]-thio]-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid,ethyl ester (108931-96-0)

Guidance literature:

With citric acid; at 100 ℃; for 8h;

DOI:10.1021/jo00286a020

Reference yield:

1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid ethyl ester (106720-60-9) + chloroformic acid ethyl ester (541-41-3) → 2-methoxy-4-methyl-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid, diethyl ester (111199-77-0)

Guidance literature:

With pyridine; In dichloromethane; for 0.5h; Ambient temperature;

DOI:10.1021/jo00286a020

upstream raw materials:

ethyl (Z)-2-(3-nitrobenzylidene)-3-oxobutanoate

2-methyl-isourea

Downstream raw materials:

2-Methoxy-4-methyl-6-(3-nitro-phenyl)-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-ethyl ester

nifetepimine

2-Methoxy-4-methyl-6-(3-nitro-phenyl)-1-propionyl-1,6-dihydro-pyrimidine-5-carboxylic acid ethyl ester

2-methoxy-4-methyl-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid, diethyl ester

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