Technology Process of diethyl (4-ethylcyclohexanon-3-yl)malonate
There total 4 articles about diethyl (4-ethylcyclohexanon-3-yl)malonate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
diethyl malonate;
With
sodium ethanolate;
In
ethanol;
at 0 ℃;
for 0.25h;
4-ethyl-2-cyclohexen-1-one;
In
ethanol;
at 20 ℃;
for 16h;
DOI:10.1002/jhet.5570370103
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 78 percent / bromine / 20 °C
2.1: 79 percent / sodium methoxide / dimethylsulfoxide / 4 h / 80 °C
3.1: 74 percent / 5 percent H2SO4 / dioxane / 0.5 h / 20 °C
4.1: sodium ethylate / ethanol / 0.25 h / 0 °C
4.2: 95 percent / ethanol / 16 h / 20 °C
With
sulfuric acid; bromine; sodium methylate; sodium ethanolate;
In
1,4-dioxane; ethanol; dimethyl sulfoxide;
1.1: Cycloaddition / 2.1: Dehydrobromination / 3.1: Hydrolysis / 4.1: Metallation / 4.2: Addition;
DOI:10.1002/jhet.5570370103
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 74 percent / 5 percent H2SO4 / dioxane / 0.5 h / 20 °C
2.1: sodium ethylate / ethanol / 0.25 h / 0 °C
2.2: 95 percent / ethanol / 16 h / 20 °C
With
sulfuric acid; sodium ethanolate;
In
1,4-dioxane; ethanol;
1.1: Hydrolysis / 2.1: Metallation / 2.2: Addition;
DOI:10.1002/jhet.5570370103
