4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-6-ethyl-5-ethylsulfanylcarbonyl-2-phenyl-nicotinic acid ethyl ester

Base Information

• Chemical Name: 4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-6-ethyl-5-ethylsulfanylcarbonyl-2-phenyl-nicotinic acid ethyl ester
• CAS No.: 223679-00-3
• Molecular Formula: C₃₀H₃₀N₂O₅S
• Molecular Weight: 530.645

Synonyms:4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-6-ethyl-5-ethylsulfanylcarbonyl-2-phenyl-nicotinic acid ethyl ester

Chemical Property of 4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-6-ethyl-5-ethylsulfanylcarbonyl-2-phenyl-nicotinic acid ethyl ester

Chemical Property:

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Technology Process of 4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-6-ethyl-5-ethylsulfanylcarbonyl-2-phenyl-nicotinic acid ethyl ester

There total 6 articles about 4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-6-ethyl-5-ethylsulfanylcarbonyl-2-phenyl-nicotinic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-6-ethyl-5-ethylsulfanylcarbonyl-2-phenyl-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester (1026634-99-0) → 4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-6-ethyl-5-ethylsulfanylcarbonyl-2-phenyl-nicotinic acid ethyl ester (223679-00-3)

Guidance literature:

With chloranil; In tetrahydrofuran; Yield given; Heating;

DOI:10.1021/jm980550w

Reference yield:

4-phthalimidobutanal (3598-60-5) → 4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-6-ethyl-5-ethylsulfanylcarbonyl-2-phenyl-nicotinic acid ethyl ester (223679-00-3)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 80 °C

2: tetrachloro-1,4-benzoquinone / tetrahydrofuran / Heating

With chloranil; In tetrahydrofuran; ethanol;

DOI:10.1021/jm980550w

Reference yield:

2-(4,4-diethoxybutyl)isoindoline-1,3-dione (32464-55-4) → 4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-6-ethyl-5-ethylsulfanylcarbonyl-2-phenyl-nicotinic acid ethyl ester (223679-00-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1 N aq. HCl / acetone / 2 h / Heating

2: ethanol / 80 °C

3: tetrachloro-1,4-benzoquinone / tetrahydrofuran / Heating

With hydrogenchloride; chloranil; In tetrahydrofuran; ethanol; acetone;

DOI:10.1021/jm980550w

upstream raw materials:

4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-6-ethyl-5-ethylsulfanylcarbonyl-2-phenyl-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester

4-phthalimidobutanal

2-(4,4-diethoxybutyl)isoindoline-1,3-dione

N-ethoxycarbonylphthalimide

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