(2S,4S)-1-((2R)-2-amino-3-[(4-methoxybenzyl)sulfonyl]-3-methyl-butanoyl)-4-fluoropyrrolidine-2-carbonitrile hydrochloride

Base Information

Chemical Name:(2S,4S)-1-((2R)-2-amino-3-[(4-methoxybenzyl)sulfonyl]-3-methyl-butanoyl)-4-fluoropyrrolidine-2-carbonitrile hydrochloride
CAS No.:483367-72-2
Molecular Formula:C₁₈H₂₄FN₃O₄S*ClH
Molecular Weight:433.932
Hs Code.:

Synonyms:(2S,4S)-1-((2R)-2-amino-3-[(4-methoxybenzyl)sulfonyl]-3-methyl-butanoyl)-4-fluoropyrrolidine-2-carbonitrile hydrochloride

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Chemical Property of (2S,4S)-1-((2R)-2-amino-3-[(4-methoxybenzyl)sulfonyl]-3-methyl-butanoyl)-4-fluoropyrrolidine-2-carbonitrile hydrochloride

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Technology Process of (2S,4S)-1-((2R)-2-amino-3-[(4-methoxybenzyl)sulfonyl]-3-methyl-butanoyl)-4-fluoropyrrolidine-2-carbonitrile hydrochloride

There total 1 articles about (2S,4S)-1-((2R)-2-amino-3-[(4-methoxybenzyl)sulfonyl]-3-methyl-butanoyl)-4-fluoropyrrolidine-2-carbonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 483368-47-4
tert-butyl (1R)-1-{[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]carbonyl}-2-[(4-methoxybenzyl)sulfonyl]-2-methylpropylcarbamate

: 483367-72-2
(2S,4S)-1-((2R)-2-amino-3-[(4-methoxybenzyl)sulfonyl]-3-methyl-butanoyl)-4-fluoropyrrolidine-2-carbonitrile hydrochloride

Guidance literature:: tert-butyl (1R)-1-{[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]carbonyl}-2-[(4-methoxybenzyl)sulfonyl]-2-methylpropylcarbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With water; sodium hydrogencarbonate; In dichloromethane;

With hydrogenchloride; In diethyl ether;