tert-butyl (1R)-1-{[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]carbonyl}-2-[(4-methoxybenzyl)sulfonyl]-2-methylpropylcarbamate

Base Information

Chemical Name:tert-butyl (1R)-1-{[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]carbonyl}-2-[(4-methoxybenzyl)sulfonyl]-2-methylpropylcarbamate
CAS No.:483368-47-4
Molecular Formula:C₂₃H₃₂FN₃O₆S
Molecular Weight:497.588
Hs Code.:

Synonyms:tert-butyl (1R)-1-{[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]carbonyl}-2-[(4-methoxybenzyl)sulfonyl]-2-methylpropylcarbamate

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Chemical Property of tert-butyl (1R)-1-{[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]carbonyl}-2-[(4-methoxybenzyl)sulfonyl]-2-methylpropylcarbamate

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Technology Process of tert-butyl (1R)-1-{[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]carbonyl}-2-[(4-methoxybenzyl)sulfonyl]-2-methylpropylcarbamate

There total 1 articles about tert-butyl (1R)-1-{[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]carbonyl}-2-[(4-methoxybenzyl)sulfonyl]-2-methylpropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1064078-39-2
(4S)-fluoro-L-prolinamide p-toluenesulfonate

: 120944-75-4
N-tertbutyloxycarbonyl-S-p-methoxybenzyl-L-penicillamine

: 483368-47-4
tert-butyl (1R)-1-{[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]carbonyl}-2-[(4-methoxybenzyl)sulfonyl]-2-methylpropylcarbamate

Guidance literature:: (4S)-fluoro-L-prolinamide p-toluenesulfonate; N-tertbutyloxycarbonyl-S-p-methoxybenzyl-L-penicillamine; With N-ethyl-N,N-diisopropylamine; HATU; In DMF (N,N-dimethyl-formamide); at 0 ℃; for 5h;

In methanol; at 0 ℃; for 2.5h;

Reference yield: 81.0%

: 483368-47-4
tert-butyl (1R)-1-{[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]carbonyl}-2-[(4-methoxybenzyl)sulfonyl]-2-methylpropylcarbamate

: 483368-13-4
(2S,4S)-1-((2R)-2-amino-3-[(4-methoxybenzyl)sulfonyl]-3-methylbutanoyl)-4-fluoropyrrolidine-2-carbonitrile hydrochloride

Guidance literature:: With methanesulfonic acid; In acetonitrile; at 20 ℃; for 1.5h;

Reference yield:

: 483368-47-4
tert-butyl (1R)-1-{[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]carbonyl}-2-[(4-methoxybenzyl)sulfonyl]-2-methylpropylcarbamate

: 483367-72-2
(2S,4S)-1-((2R)-2-amino-3-[(4-methoxybenzyl)sulfonyl]-3-methyl-butanoyl)-4-fluoropyrrolidine-2-carbonitrile hydrochloride

Guidance literature:: tert-butyl (1R)-1-{[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]carbonyl}-2-[(4-methoxybenzyl)sulfonyl]-2-methylpropylcarbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With water; sodium hydrogencarbonate; In dichloromethane;

With hydrogenchloride; In diethyl ether;