3-[Dimethyl-(1-methyl-1-phenyl-ethyl)-silanyloxy]-2,2-dimethyl-cyclooctanone

Base Information

• Chemical Name: 3-[Dimethyl-(1-methyl-1-phenyl-ethyl)-silanyloxy]-2,2-dimethyl-cyclooctanone
• CAS No.: 163432-24-4
• Molecular Formula: C₂₁H₃₄O₂Si
• Molecular Weight: 346.585
• Mol file: 163432-24-4.mol

Synonyms:3-[Dimethyl-(1-methyl-1-phenyl-ethyl)-silanyloxy]-2,2-dimethyl-cyclooctanone

Chemical Property of 3-[Dimethyl-(1-methyl-1-phenyl-ethyl)-silanyloxy]-2,2-dimethyl-cyclooctanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[Dimethyl-(1-methyl-1-phenyl-ethyl)-silanyloxy]-2,2-dimethyl-cyclooctanone

There total 2 articles about 3-[Dimethyl-(1-methyl-1-phenyl-ethyl)-silanyloxy]-2,2-dimethyl-cyclooctanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

chloro(α,α-dimethylbenzyl)dimethylsilane (118740-38-8) + 3-Hydroxy-2,2-dimethyl-cyclooctanone (167172-38-5) → 3-[Dimethyl-(1-methyl-1-phenyl-ethyl)-silanyloxy]-2,2-dimethyl-cyclooctanone (163432-24-4)

Guidance literature:

With 1H-imidazole; dmap; In N,N-dimethyl-formamide; for 1h; Ambient temperature;

DOI:10.1248/cpb.45.1898

Reference yield:

2,2-dimethylcyclooctane-1,3-dione (55277-52-6) → 3-[Dimethyl-(1-methyl-1-phenyl-ethyl)-silanyloxy]-2,2-dimethyl-cyclooctanone (163432-24-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / NaBH₄ / ethanol / 2 h / Ambient temperature

2: 100 percent / imidazole, DMAP / dimethylformamide / 1 h / Ambient temperature

With 1H-imidazole; dmap; sodium tetrahydroborate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.45.1898

Reference yield: 95.0%

vinyl magnesium bromide (1826-67-1) + 3-[Dimethyl-(1-methyl-1-phenyl-ethyl)-silanyloxy]-2,2-dimethyl-cyclooctanone (163432-24-4) → 3-[Dimethyl-(1-methyl-1-phenyl-ethyl)-silanyloxy]-2,2-dimethyl-1-vinyl-cyclooctanol

Guidance literature:

With cerium(III) chloride; In tetrahydrofuran; at -78 ℃;

DOI:10.1246/cl.1995.229

upstream raw materials:

chloro(α,α-dimethylbenzyl)dimethylsilane

3-Hydroxy-2,2-dimethyl-cyclooctanone

2,2-dimethylcyclooctane-1,3-dione