trans-1-(3,4-difluorophenyl)-4-[trans-4-(3,4-difluoro-4-phenylsulfinylbutyl)cyclohexyl]cyclohexane

Base Information

Chemical Name:trans-1-(3,4-difluorophenyl)-4-[trans-4-(3,4-difluoro-4-phenylsulfinylbutyl)cyclohexyl]cyclohexane
CAS No.:216303-04-7
Molecular Formula:C₂₈H₃₄F₄OS
Molecular Weight:494.637
Hs Code.:

Synonyms:trans-1-(3,4-difluorophenyl)-4-[trans-4-(3,4-difluoro-4-phenylsulfinylbutyl)cyclohexyl]cyclohexane

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Chemical Property of trans-1-(3,4-difluorophenyl)-4-[trans-4-(3,4-difluoro-4-phenylsulfinylbutyl)cyclohexyl]cyclohexane

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Technology Process of trans-1-(3,4-difluorophenyl)-4-[trans-4-(3,4-difluoro-4-phenylsulfinylbutyl)cyclohexyl]cyclohexane

There total 4 articles about trans-1-(3,4-difluorophenyl)-4-[trans-4-(3,4-difluoro-4-phenylsulfinylbutyl)cyclohexyl]cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 291300-67-9
4-(3,4-difluoro-phenyl)-4'-(3,4-difluoro-4-phenylsulfanyl-butyl)-bicyclohexyl

: 216303-04-7
trans-1-(3,4-difluorophenyl)-4-[trans-4-(3,4-difluoro-4-phenylsulfinylbutyl)cyclohexyl]cyclohexane

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -30 ℃; for 3h; Yield given;
DOI:10.1246/cl.1998.1169

Reference yield:

: 14204-27-4
N-phenylthiophthalimide

: 216303-04-7
trans-1-(3,4-difluorophenyl)-4-[trans-4-(3,4-difluoro-4-phenylsulfinylbutyl)cyclohexyl]cyclohexane

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / HF/pyridine / CH₂Cl₂ / 53 h / 20 °C

2: tetrabutylammonium dihydrogentrifluoride; 1,3-dibromo-5,5-dimethylhydantoin / CH₂Cl₂ / 0.5 h / 20 °C

3: 1.39 g / m-chloroperbenzoic acid / CH₂Cl₂ / 3 h / -30 °C

With pyridine; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; hydrogen fluoride; tetra-n-butylammonium dihydrogen trifluoride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; 1: thio-fluorination / 2: Fluorination / 3: Oxidation;
DOI:10.1246/bcsj.73.1633

Reference yield:

: 155266-68-5
1-[trans-4-(3-butenyl)cyclohexyl]-trans-4-(3,4-difluorophenyl)cyclohexane

: 216303-04-7
trans-1-(3,4-difluorophenyl)-4-[trans-4-(3,4-difluoro-4-phenylsulfinylbutyl)cyclohexyl]cyclohexane

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / HF/pyridine / CH₂Cl₂ / 53 h / 20 °C

2: tetrabutylammonium dihydrogentrifluoride; 1,3-dibromo-5,5-dimethylhydantoin / CH₂Cl₂ / 0.5 h / 20 °C

3: 1.39 g / m-chloroperbenzoic acid / CH₂Cl₂ / 3 h / -30 °C

With pyridine; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; hydrogen fluoride; tetra-n-butylammonium dihydrogen trifluoride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; 1: thio-fluorination / 2: Fluorination / 3: Oxidation;
DOI:10.1246/bcsj.73.1633