4-(3,4-difluoro-phenyl)-4'-(3,4-difluoro-4-phenylsulfanyl-butyl)-bicyclohexyl

Base Information

Chemical Name:4-(3,4-difluoro-phenyl)-4'-(3,4-difluoro-4-phenylsulfanyl-butyl)-bicyclohexyl
CAS No.:291300-67-9
Molecular Formula:C₂₈H₃₄F₄S
Molecular Weight:478.638
Hs Code.:

Synonyms:4-(3,4-difluoro-phenyl)-4'-(3,4-difluoro-4-phenylsulfanyl-butyl)-bicyclohexyl

Suppliers and Price of 4-(3,4-difluoro-phenyl)-4'-(3,4-difluoro-4-phenylsulfanyl-butyl)-bicyclohexyl

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(3,4-difluoro-phenyl)-4'-(3,4-difluoro-4-phenylsulfanyl-butyl)-bicyclohexyl

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(3,4-difluoro-phenyl)-4'-(3,4-difluoro-4-phenylsulfanyl-butyl)-bicyclohexyl

There total 3 articles about 4-(3,4-difluoro-phenyl)-4'-(3,4-difluoro-4-phenylsulfanyl-butyl)-bicyclohexyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 216244-32-5
1-{trans-4-[3-fluoro-4-(phenylthio)butyl]cyclohexyl}-trans-4-(3,4-difluorophenyl)cyclohexane

: 291300-67-9
4-(3,4-difluoro-phenyl)-4'-(3,4-difluoro-4-phenylsulfanyl-butyl)-bicyclohexyl

Guidance literature:: With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; tetra-n-butylammonium dihydrogen trifluoride; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1246/cl.1998.1169

Reference yield:

: 14204-27-4
N-phenylthiophthalimide

: 291300-67-9
4-(3,4-difluoro-phenyl)-4'-(3,4-difluoro-4-phenylsulfanyl-butyl)-bicyclohexyl

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / HF/pyridine / CH₂Cl₂ / 53 h / 20 °C

2: tetrabutylammonium dihydrogentrifluoride; 1,3-dibromo-5,5-dimethylhydantoin / CH₂Cl₂ / 0.5 h / 20 °C

With pyridine; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; hydrogen fluoride; tetra-n-butylammonium dihydrogen trifluoride; In dichloromethane; 1: thio-fluorination / 2: Fluorination;
DOI:10.1246/bcsj.73.1633

Reference yield:

: 155266-68-5
1-[trans-4-(3-butenyl)cyclohexyl]-trans-4-(3,4-difluorophenyl)cyclohexane

: 291300-67-9
4-(3,4-difluoro-phenyl)-4'-(3,4-difluoro-4-phenylsulfanyl-butyl)-bicyclohexyl

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / HF/pyridine / CH₂Cl₂ / 53 h / 20 °C

2: tetrabutylammonium dihydrogentrifluoride; 1,3-dibromo-5,5-dimethylhydantoin / CH₂Cl₂ / 0.5 h / 20 °C

With pyridine; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; hydrogen fluoride; tetra-n-butylammonium dihydrogen trifluoride; In dichloromethane; 1: thio-fluorination / 2: Fluorination;
DOI:10.1246/bcsj.73.1633